Oxalate and Citrate Drink for Kidney Stones
What You Need to Know Before You Apply
What is the purpose of this trial?
This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones.
Will I have to stop taking my current medications?
If you are taking diuretic medication or alkali supplements, you will need to stop them for the duration of the study.
Is the Oxalate and Citrate Drink safe for humans?
How does the oxalate and citrate drink treatment for kidney stones differ from other treatments?
The oxalate and citrate drink is unique because it combines citrate, which helps prevent stone formation, with oxalate, potentially offering a novel approach to managing kidney stones compared to standard potassium citrate therapy. This drink may provide a more accessible and possibly cost-effective alternative to traditional medications.13467
What data supports the effectiveness of the treatment for kidney stones?
Research shows that potassium-magnesium citrate can help prevent the recurrence of calcium oxalate kidney stones by increasing urinary citrate and magnesium, which are known to inhibit stone formation. Additionally, potassium citrate has been effective in managing various types of kidney stones, including those associated with renal tubular acidosis and uric acid.13789
Are You a Good Fit for This Trial?
This trial is for adults aged 18-70 who either have a history of calcium-based kidney stones or no history at all (controls). Participants should have normal urine oxalate levels. Those with a history of non-calcium stones, severe acid-base issues, or extreme urine citrate levels cannot join.Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-study Preparation
Participants discontinue certain supplements and medications, complete a 24-hour urine collection and food frequency questionnaire at home
Study Day
Participants consume a 360mg oral sodium oxalate load and undergo urine and blood sampling over 6 hours
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Citrate
- Oxalate
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Chicago
Lead Sponsor