75 Participants Needed

Healthy Lifestyle Intervention for Obesity in Teens

(LIFT Trial)

SE
RB
Overseen ByRashon Braxton
Age: < 65
Sex: Any
Trial Phase: Academic
Sponsor: The University of Texas Health Science Center, Houston
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Do I need to stop taking my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the Healthy Lifestyle Behavioral Intervention treatment for obesity in teens?

Research shows that lifestyle interventions, which include nutrition education, behavior therapy, and exercise, are effective for weight loss in children and teens. These interventions have been proven to improve health factors like cardiovascular risk and quality of life, especially when parents are involved.12345

Is the Healthy Lifestyle Intervention for Obesity in Teens safe?

The studies reviewed did not report any safety concerns for healthy lifestyle interventions in adolescents, suggesting they are generally safe for human participants.678910

How is the Healthy Lifestyle Behavioral Intervention treatment for obesity in teens different from other treatments?

The Healthy Lifestyle Behavioral Intervention is unique because it focuses on promoting a healthy lifestyle rather than just weight loss, emphasizing both physical and mental well-being. It is tailored to adolescent preferences, including having relatable instructors and engaging activities, which may improve its effectiveness and appeal to teens.69111213

What is the purpose of this trial?

This trial tests if combining weight-loss surgery with healthy living advice works well for teenagers who need extra help losing weight.

Research Team

SE

Sarah E Messiah, Ph.D., MPH

Principal Investigator

The University of Texas Health Science Center, Houston

Eligibility Criteria

This trial is for teens with severe obesity, defined as having a BMI over 35 with related health issues like high blood pressure or cholesterol, or a BMI over 40. They must be considered candidates for bariatric surgery according to NIH guidelines and have received psychological clearance.

Inclusion Criteria

I am eligible for weight loss surgery based on my BMI and health conditions.
I am eligible for weight loss surgery based on my BMI and health conditions.
I have been cleared by a psychologist for surgery.

Exclusion Criteria

I do not want to participate in the study.
I have not been referred for weight loss surgery by a doctor.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Pre-surgery

Participants undergo pre-surgery assessments and preparation

1 month

Surgery

Participants undergo metabolic and bariatric surgery

Post-surgery Treatment

Participants receive a healthy lifestyle behavioral intervention supported by the clinical team

6 months

Follow-up

Participants are monitored for safety and effectiveness after treatment

6 months

Treatment Details

Interventions

  • Healthy Lifestyle Behavioral Intervention
Trial Overview The study tests a healthy lifestyle behavioral intervention supported by Metabolic and Bariatric Surgery (MBS) teams. It aims to see if this approach is feasible, acceptable, and effective in helping obese adolescents and their families make positive changes.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: TreatmentExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

The University of Texas Health Science Center, Houston

Lead Sponsor

Trials
974
Recruited
361,000+

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Collaborator

Trials
2,103
Recruited
2,760,000+

Findings from Research

Both short-stay (2 months) and long-stay (6 months) intensive lifestyle treatments for severely obese children resulted in significant reductions in SDS-BMI after one year, indicating that both approaches are effective.
There were no significant differences in outcomes between the two treatment durations, suggesting that the shorter treatment may be preferable due to its lower burden on children and families.
One-year effects of two intensive inpatient treatments for severely obese children and adolescents.Makkes, S., Renders, CM., Bosmans, JE., et al.[2023]
In a study involving 686 obese children aged 7-13, inpatient lifestyle treatment led to a significant short-term decrease in BMI-SDS, but long-term weight maintenance results were similar regardless of whether parents received additional cognitive-behavioral training or just written information.
Both groups showed improvements in quality of life, healthy food intake, and exercise, indicating that while inpatient treatment is effective, the inclusion of parent training did not enhance long-term outcomes for weight maintenance or psychosocial well-being.
Empowering Parents of Obese Children (EPOC): A randomized controlled trial on additional long-term weight effects of parent training.Warschburger, P., Kroeller, K., Haerting, J., et al.[2019]
In a study of 568 children and adolescents with severe obesity, 73% attended a one-year follow-up, showing a moderate mean reduction in key weight measures, including BMI and waist circumference, indicating that lifestyle interventions can be effective in this population.
About 65% of participants achieved a reduction in their percentage overweight, with 17% moving from severe obesity to obesity, highlighting that while the interventions had positive outcomes, individual responses varied significantly.
Lifestyle intervention for children and adolescents with severe obesity - results after one year.Skodvin, VA., Lekhal, S., Kommedal, KG., et al.[2021]

References

One-year effects of two intensive inpatient treatments for severely obese children and adolescents. [2023]
Long-term effect of lifestyle intervention on adiposity, metabolic parameters, inflammation and physical fitness in obese children: a randomized controlled trial. [2021]
Empowering Parents of Obese Children (EPOC): A randomized controlled trial on additional long-term weight effects of parent training. [2019]
Long-term follow-up of obesity in adolescents. [2019]
Effectiveness of lifestyle intervention in overweight children. [2019]
Lifestyle intervention for children and adolescents with severe obesity - results after one year. [2021]
Evaluation of a group family-based intervention programme for adolescent obesity: the LITE randomised controlled pilot trial. [2023]
A Family-Based Healthy Lifestyle Intervention: Crossover Effects on Substance Use and Sexual Risk Behaviors. [2022]
Behavioral Weight Loss Intervention Preferences of Adolescents with Overweight/Obesity. [2022]
The Coaching on Lifestyle (CooL) Intervention for Overweight and Obesity: A Longitudinal Study into Participants' Lifestyle Changes. [2019]
Extremely obese children respond better than extremely obese adolescents to lifestyle interventions. [2022]
Weight Loss Strategies. [2022]
End-user perspectives to inform policy and program decisions: a qualitative and quantitative content analysis of lifestyle treatment recommendations by adolescents with obesity. [2020]
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top
Terms of Service·Privacy Policy·Cookies·Security