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Stem Cell Therapy

Stem Cells + Light Therapy for Alzheimer's Disease and Autism (ACIST Trial)

N/A
Waitlist Available
Led By Jeffrey Weiss, MD
Research Sponsored by MD Stem Cells
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Have documented cognitive impairment or diagnosis of disease associated with cognitive impairment such as Alzheimer's Disease, Autism Spectrum Disorder.
Have documented cognitive impairment or diagnosis of disease associated with cognitive impairment such as Alzheimer's Disease, Autism Spectrum Disorder.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1,3,6,and 12 months post treatment
Awards & highlights

ACIST Trial Summary

This trial is testing whether stem cells from patients' own bone marrow can improve cognitive impairment and socialization issues in adults with Alzheimer's or autism. Near-infrared light therapy will also be tested.

Who is the study for?
This trial is for adults over 18 with cognitive impairments or diagnoses like Alzheimer's, various dementias, Autism Spectrum Disorder, and other brain diseases. They should be stable on current treatments and have potential to benefit from BMSC treatment without significant risk. Pregnant women or those who may become pregnant within 3 months post-treatment are excluded.Check my eligibility
What is being tested?
The study tests autologous Bone Marrow Derived Stem Cells (BMSC) administered intravenously and topically through the nose, along with Near Infrared Light therapy. It aims to improve cognitive function in dementia and behavior in adult autism.See study design
What are the potential side effects?
Potential side effects aren't specified but participants must be at minimal risk of harm from BMSC treatment as assessed by investigators. Medical clearance is required indicating they can undergo the procedure safely.

ACIST Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been diagnosed with a condition that affects my thinking, like Alzheimer's or Autism.
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I have been diagnosed with a condition that affects my thinking, like Alzheimer's or Autism.
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I have been diagnosed with a condition like Alzheimer's or Autism that affects my thinking.
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My doctor agrees I can safely undergo a medical procedure.
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I am over 18 years old.
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I am over 18 years old.
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My doctor believes BMSC treatment could help me with minimal risk.
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My current treatment for my condition is stable and not expected to reverse my cognitive issues.

ACIST Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1,3,6,and 12 months post treatment
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1,3,6,and 12 months post treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Autism Spectrum Quotient Exam
Mini-Mental Status Exam (MMSE)
Secondary outcome measures
Activities of Daily Living

ACIST Trial Design

3Treatment groups
Active Control
Group I: Arm 1Active Control1 Intervention
Intravenous Bone Marrow Stem Cell (BMSC) Fraction
Group II: Arm 2Active Control2 Interventions
Intravenous Bone Marrow Stem Cell (BMSC) Fraction combined with Near Infrared Light exposure .
Group III: Arm 3Active Control2 Interventions
Intravenous Bone Marrow Stem Cell (BMSC) Fraction combined with Intranasal topical Bone Marrow Stem Cell (BMSC) Fraction.

Find a Location

Who is running the clinical trial?

MD Stem CellsLead Sponsor
4 Previous Clinical Trials
1,340 Total Patients Enrolled
1 Trials studying Lewy Body Disease
500 Patients Enrolled for Lewy Body Disease
Steven Levy, MDStudy ChairMD Stem Cells
4 Previous Clinical Trials
1,340 Total Patients Enrolled
1 Trials studying Lewy Body Disease
500 Patients Enrolled for Lewy Body Disease
Jeffrey Weiss, MDPrincipal InvestigatorCoral Springs
4 Previous Clinical Trials
1,340 Total Patients Enrolled
1 Trials studying Lewy Body Disease
500 Patients Enrolled for Lewy Body Disease

Media Library

Intranasal Topical Bone Marrow Stem Cell (BMSC) Fraction (Stem Cell Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT03724136 — N/A
Lewy Body Disease Research Study Groups: Arm 1, Arm 2, Arm 3
Lewy Body Disease Clinical Trial 2023: Intranasal Topical Bone Marrow Stem Cell (BMSC) Fraction Highlights & Side Effects. Trial Name: NCT03724136 — N/A
Intranasal Topical Bone Marrow Stem Cell (BMSC) Fraction (Stem Cell Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03724136 — N/A
Lewy Body Disease Patient Testimony for trial: Trial Name: NCT03724136 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are researchers currently accepting participants for this experiment?

"Based on the data provided by clinicaltrials.gov, this study has ceased to seek out new participants as of August 1st 2022. Despite this fact, there are 4119 other medical trials that are currently welcoming patients into their ranks."

Answered by AI

Who else is applying?

What state do they live in?
Ontario
Other
Connecticut
Massachusetts
How old are they?
65+
18 - 65
What site did they apply to?
MD Stem Cells
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
2
1
0

Why did patients apply to this trial?

Would like to help with a cure! I've only tried L-DOPA and I would like to try new medications and stem cell transplant.
PatientReceived 1 prior treatment
I have cadasll and 5 children...I will do anything I can to help their future, I love them with all my heart!
PatientReceived 2+ prior treatments
I have read about stem cell therapy and am excited it could help me when nothing else has. I have watched two brother die of CADASIL.
PatientReceived no prior treatments
My daughter is a sweet girl who could really use some help. I know that the study said it for adults, but I (Kate's father) wasn't certain if an exception could be made.
PatientReceived 2+ prior treatments

What questions have other patients asked about this trial?

How many visits? Do I need to go to Florida for all aspects of the study?
PatientReceived 2+ prior treatments

How responsive is this trial?

Average response time
  • < 2 Days
Typically responds via
Email
Most responsive sites:
  1. MD Stem Cells: < 24 hours
Recent research and studies
~8 spots leftby Oct 2024