20 Participants Needed

The CoAGulation Biomarkers and Atrial Fibrillation (COAG-AF) Pilot Study

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NM
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Overseen ByQuintrele Jones, MPH
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Tulane University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

The aim of the Correlation Of CoAGulation-Atrial Fibrillation (COAG-AF) study is to prove that an increase in pro-thrombotic biomarkers in AF is associated with an increase in AF burden.Secondary objectives of the study are the following:* To investigate the impact of catheter ablation on serum pro-thrombotic biomarkers in patients with AF.* To correlate coagulation biomarkers with imaging features such as, the degree of fibrosis found on Late Gadolinium Enhancement Magnetic Resonance Imaging (LGE-MRI) scans, which is a part of standard of care.* To determine baseline values of coagulation and pro-thrombotic biomarkers in the AF population and compare those baseline values with the general population values.* To compare central and peripheral thrombotic biomarkers in patients with atrial fibrillation.

Research Team

NM

Nassir Marrouche, MD

Principal Investigator

Tulane University

Eligibility Criteria

Inclusion Criteria

Patients diagnosed with persistent or paroxysmal AF.
Patients that are undergoing catheter ablation at Tulane University Medical Center.
Patients that had a cardiac MRI prescribed by their physician as part of their standard of care.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Baseline blood draw and cardiac MRI (LGE-MRI) scan performed prior to ablation

1 day
1 visit (in-person)

Ablation and Immediate Post-Ablation

Catheter ablation procedure with blood samples taken during and immediately after the procedure

1 day
1 visit (in-person)

Follow-up

Blood draws and monitoring of atrial fibrillation burden using ECG patch at 1 month and 3 months post-ablation

3 months
2 visits (in-person)

Treatment Details

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Who Is Running the Clinical Trial?

Tulane University

Lead Sponsor

Trials
129
Recruited
259,000+
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