Metabolic Dysfunction and Mucus Plugging for Asthma
(IMAP Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to understand the effects of obesity, metabolic issues, and mucus buildup on asthma. Researchers will use cardiopulmonary exercise testing to assess lung function and oxygen levels in people with asthma. The trial seeks participants with asthma who also experience obesity or severe asthma and have noticeable symptoms like mucus buildup. By revealing how these factors impact asthma, this trial could improve treatments. As an unphased trial, it offers participants the chance to contribute to groundbreaking research that could lead to better asthma management strategies.
Do I need to stop my current medications for the trial?
The trial information does not specify if you need to stop your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that cardiopulmonary exercise testing is safe for asthma patients?
Research shows that Cardiopulmonary Exercise Testing (CPET) is generally safe. Studies indicate a very low risk of serious problems. For instance, one study found major issues in only 0.6% of tests and minor issues in 9.3% of tests. Importantly, no deaths or heart attacks were reported within 48 hours after testing.
Another source mentions that the chance of death from CPET is between 2 and 5 out of every 100,000 tests. This indicates that CPET is well-tolerated and considered safe, even for individuals with heart conditions.
In summary, CPET has a strong safety record. While small risks exist, the procedure is generally safe for most people.12345Why are researchers excited about this trial?
Researchers are excited about Cardiopulmonary Exercise Testing (CPET) for asthma because it provides a unique way to assess how metabolic dysfunction and mucus plugging affect asthma physiology. Unlike traditional asthma treatments that focus on controlling symptoms with inhalers or medications, CPET measures how well the lungs, heart, and muscles work together during exercise. This comprehensive approach can reveal underlying issues that typical treatments might overlook, potentially leading to more personalized and effective management strategies for asthma patients.
What evidence suggests that cardiopulmonary exercise testing is effective for asthma?
Research shows that cardiopulmonary exercise testing (CPET) safely and reliably assesses heart and lung function during exercise. It helps doctors understand heart and lung fitness. Studies have found that CPET provides important information to assess health risks and guide treatment choices. While it doesn't directly treat asthma, it evaluates how asthma affects exercise ability. This information is crucial for personalizing asthma care, especially for patients with complex issues like obesity or mucus buildup.46789
Who Is on the Research Team?
John Fahy, MD, MS
Principal Investigator
University of California, San Francisco
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Cardiopulmonary Exercise Testing (CPET)
Participants undergo CPET to compare lung function markers and changes in oxygen saturation
Follow-up
Participants are monitored for safety and effectiveness after CPET
What Are the Treatments Tested in This Trial?
Interventions
- Cardiopulmonary Exercise Testing
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, San Francisco
Lead Sponsor
National Institutes of Health (NIH)
Collaborator
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Citations
Cardiopulmonary exercise testing—a beginner's guide to ...
In this example, the CPET software predicted a maximum work of 178 W and the patient achieved a maximum of 221 W during the test (124%). (ii). Achieving a HR of > ...
Cardiopulmonary Exercise Test Interpretation Across the ...
The presence of exercise oscillatory ventilation is associated with 3.9 times increased hazard of death, transplant, and nonelective ...
ATS/ACCP Statement on Cardiopulmonary Exercise Testing
CPET is a safe procedure, with the risk of death for patients between 2 and 5 per 100,000 exercise tests performed. For all tests, attention to patient safety ...
A cohort study based on routinely collected data | PLOS One
Cardiopulmonary exercise testing (CPET) provides objective measures of cardiorespiratory fitness and can support surgical risk stratification. As socioeconomic ...
5.
respiratory-research.biomedcentral.com
respiratory-research.biomedcentral.com/articles/10.1186/s12931-021-01895-6Practical guide to cardiopulmonary exercise testing in adults
This article describes the underlying principles of exercise physiology and provides a practical guide to performing CPET and interpreting the results in ...
The Safety of Cardiopulmonary Exercise Testing in a ...
The 2002 American Heart Association exercise testing guidelines cite an adverse event rate of up to 0.04% or 1 per 2500 tests. ... This figure is ...
The safety of cardiopulmonary exercise testing in a ...
Conclusions: CPX is generally a safe procedure, even in a population with underlying high-risk cardiovascular diagnoses. MeSH terms. Adult; Aged ...
Safety of cardiopulmonary exercise testing in a large ...
A major event occurred in 56 (0.6%) tests and a minor event in 870 (9.3%) tests. There were no deaths within 48 hours, nor cardiac arrests ...
UTILITY AND SAFETY OF CARDIOPULMONARY ...
CPET appears to be a safe and excellent predictive tool for risk stratification in patients with HCM regardless of severity of resting left ...
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