Osteochondral Allograft for Arthritis
Trial Summary
Do I need to stop my current medications for this trial?
The trial protocol does not specify whether you need to stop taking your current medications.
What data supports the idea that Osteochondral Allograft for Arthritis is an effective treatment?
The available research shows that Osteochondral Allograft (OCA) transplantation is an effective treatment for knee issues, particularly for chondral and osteochondral defects. One study highlights that OCA is a useful option for treating these defects in the knee, suggesting it can restore function by transferring healthy tissue to damaged areas. Another study indicates that OCA is often used when other treatments have failed, implying its effectiveness as a backup option. However, the research also notes that while OCA can be beneficial, it may have a higher failure rate in the ankle, especially in young patients, and sometimes requires additional procedures.12345
What safety data is available for osteochondral allograft transplantation?
Osteochondral allograft transplantation (OCA) is generally considered a safe and effective treatment for large, full-thickness cartilage defects in the knee. Studies indicate satisfactory clinical outcomes and a reasonable rate of return to play among athletes. Factors such as young age and prior bony realignment procedures may decrease the risk of failure. However, variability in outcomes and graft survival rates has been noted, and OCA is often used as a salvage procedure after other treatments have failed.23567
Is Osteochondral Allograft a promising treatment for arthritis?
What is the purpose of this trial?
This is a study comparing the current standard of care surgical treatment to a newer surgical procedure involving the implantation of osteochondral allograft at the base of the thumb. Patients will be followed at 1, 3, 6 months and 1 year post-operatively.
Research Team
Melvin P Rosenwasser, MD
Principal Investigator
Columbia University
Eligibility Criteria
This trial is for adults over 18 who need surgery to manage basal joint arthritis, which affects the base of the thumb. Participants must be suitable candidates for surgical intervention.Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Surgical Treatment
Participants undergo either Ligament Reconstruction Tendon Interposition (LRTI) or Osteochondral Allograft procedure
Post-operative Follow-up
Participants are monitored at 1, 3, 6 months and 1 year post-operatively for safety and effectiveness
Treatment Details
Interventions
- Ligament Reconstruction Tendon Interposition
- Osteochondral Allograft
Osteochondral Allograft is already approved in United States, European Union for the following indications:
- Large full-thickness chondral defects
- Osteochondritis dissecans
- Focal avascular necrosis
- Post-traumatic osteoarthritis
- Symptomatic full-thickness osteochondral lesions larger than 3 cm
- Chondral lesions associated with diseased subchondral bone
Find a Clinic Near You
Who Is Running the Clinical Trial?
Columbia University
Lead Sponsor