Biomarker Study for Frontotemporal Dementia
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to better understand frontotemporal lobar degeneration (a brain disorder) by analyzing blood samples from individuals with specific genetic mutations linked to the condition. Researchers will compare these samples to those from individuals without these mutations. The trial does not involve testing any treatments. It suits individuals already participating in the ALLFTD study and from families with known mutations in the C9orf72, GRN, or MAPT genes. As an unphased trial, this study allows participants to contribute to foundational research that could lead to future breakthroughs in understanding and treating this condition.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.
Why are researchers excited about this trial?
The Neurofilament Surveillance Project is exciting because it aims to develop a new way of monitoring neurodegenerative diseases, like multiple sclerosis or Alzheimer's, without relying on invasive procedures. Unlike current methods that often depend on MRI scans or lumbar punctures, this project explores the potential of neurofilament proteins in the blood as biomarkers. Researchers are hopeful that this could lead to earlier detection and more precise tracking of disease progression, ultimately improving patient outcomes and treatment personalization.
Who Is on the Research Team?
Adam Boxer, MD, PhD
Principal Investigator
University of California, San Francisco
Bradley Boeve, MD
Principal Investigator
Mayo Clinic
Howie Rosen, MD
Principal Investigator
University of California, San Francisco
Laura Mitic, PhD
Principal Investigator
The Bluefield Project to Cure Frontotemporal Dementia
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Remote Blood Collection
Participants provide blood samples remotely via visits from traveling mobile research nurses
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- None
Find a Clinic Near You
Who Is Running the Clinical Trial?
The Bluefield Project to Cure Frontotemporal Dementia
Lead Sponsor
Mayo Clinic
Collaborator
University of California, San Francisco
Collaborator