NMES + ECC for ACL Injury
(MiACLR Trial)
Trial Summary
What is the purpose of this trial?
This clinical trial evaluates interventions to maximize muscle function and improve cartilage health following anterior cruciate ligament reconstruction. Improving muscle function may improve patient outcomes, improve joint mechanics, and potentially serve as a prevention approach for post-traumatic knee osteoarthritis. Knee osteoarthritis (OA) is a disabling disease that carries a substantial burden to society and to the individual affected.
Eligibility Criteria
This trial is for individuals with a complete ACL rupture who are scheduled for ACL reconstruction at the University of Michigan. Participants must be willing to follow the study's procedures and have an autograft procedure. Pregnant women, those planning pregnancy, patients with accompanying bony fractures or knee dislocations, or previous knee surgeries cannot join.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive NMES or NMES placebo for 8 weeks followed by eccentric exercise or placebo for another 8 weeks, alongside standard ACL rehabilitation
Follow-up
Participants are monitored for muscle strength and cartilage health at 6 and 18 months post-ACL reconstruction
Treatment Details
Interventions
- Eccentric Exercise (ECC)
- Eccentric Exercise (ECC) placebo
- Neuromuscular Electrical Stimulation (NMES)
- Neuromuscular Electrical Stimulation (NMES) placebo
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Michigan
Lead Sponsor
University of North Carolina, Chapel Hill
Collaborator
University of Delaware
Collaborator
University of Connecticut
Collaborator
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborator