Video Recordings for ALS

(VITALS Trial)

Not yet recruiting at 6 trial locations
PJ
KM
Overseen ByKelly M Goedert, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Trustees of Dartmouth College
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

Amyotrophic lateral sclerosis (ALS) is a fatal, rare neurodegenerative disease affecting 30,000 people in the United States. The gold standard of care for people with ALS is multidisciplinary clinics (MDC). In these multidisciplinary clinics, which occur every 3 to 4 months, people with ALS see up to 12 different healthcare providers (e.g., speech therapy, physical therapy, the ALS doctor). These clinics can last from three to five hours, and across these three to five hours people with ALS and their caregivers receive a lot of information that is critical to the care and quality of life for people with ALS. However, this information can be difficult to remember given the large amount of information that is conveyed. The current standard for providing take-home information about the visit is to provide patients with a written after-visit summary and access to their doctor's notes about the visit, typically through the patient portal. This study tests whether providing participants with video recordings of their MDC visits improves their quality of life and the quality of life of their caregivers. The study will enroll 400 pairs of people with ALS and their caregivers from eight different sites in the United States. Half of the participants in the study will receive their after-visit summary notes (the NOTES condition) and the other half of the participants will receive both their summary notes, but will also receive video recordings of their MDC visits that they can watch on their own at home (the VIDEO condition). The study will last for 12 months, with participants receiving NOTES or VIDEO at each of their regularly-scheduled MDCs during the 12 months. The study will test whether caregiver and patient participants in the VIDEO condition experience better quality of life than those in the NOTES condition at 1 month, 6 months, and 12 months from study enrollment. The results of this study will help determine what is the most effective approach to communicating MDC information to people with ALS and their caregivers.

Who Is on the Research Team?

SB

Suma Babu, MD

Principal Investigator

Massachusetts General Hospital

PJ

Paul J Barr, PhD

Principal Investigator

Dartmouth College

Are You a Good Fit for This Trial?

Inclusion Criteria

* Projected life expectancy of at least 12 months as determined by the site investigator.
* Plan to attend MDC visits for 12 months
* Diagnosis of ALS by either El- Escorial or Gold Coast Criteria
See 3 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants attend multidisciplinary clinics every 3 months, receiving either NOTES or VIDEO interventions

12 months
4 visits (in-person)

Follow-up

Participants are monitored for quality of life and adherence to treatment recommendations

12 months

What Are the Treatments Tested in This Trial?

Interventions

  • Video Recording

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: VIDEOExperimental Treatment2 Interventions
Group II: NOTESActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Trustees of Dartmouth College

Lead Sponsor

Trials
32
Recruited
14,500+

Patient-Centered Outcomes Research Institute

Collaborator

Trials
592
Recruited
27,110,000+

Massachusetts General Hospital

Collaborator

Trials
3,066
Recruited
13,430,000+

University of Pittsburgh Medical Center

Collaborator

Trials
78
Recruited
77,600+

University of Wisconsin, Madison

Collaborator

Trials
1,249
Recruited
3,255,000+

Mayo Clinic

Collaborator

Trials
3,427
Recruited
3,221,000+

Dartmouth-Hitchcock Medical Center

Collaborator

Trials
548
Recruited
2,545,000+

Penn State Health Milton S Hershey Medical Center

Collaborator

Trials
1
Recruited
1,100+