Phototherapy Garments for Psoriasis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests special clothing that uses light therapy (also known as phototherapy) to treat skin conditions such as psoriasis, alopecia areata (hair loss), and polymorphous light eruption (a rash caused by sunlight). The researchers aim to determine if wearing these garments daily for 12 weeks can improve these conditions by calming the immune system and reducing skin cell overgrowth. Individuals in the U.S. diagnosed with mild to severe cases of these conditions may qualify to participate. As an unphased trial, this study offers a unique opportunity to explore innovative treatments that could enhance quality of life.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, it does exclude participants who are currently using other forms of phototherapy.
What prior data suggests that these phototherapy garments are safe for treating psoriasis, alopecia areata, and polymorphous light eruption?
Research has shown that phototherapy is generally safe for treating psoriasis. Studies indicate that UVB light therapy ranks among the safest options for this skin condition when used correctly. The Light Treatment Effectiveness (LITE) study found that home phototherapy is as safe and effective as clinic-based treatment.
For alopecia areata, some studies have found that phototherapy can yield positive results with few side effects. This treatment uses specific types of light to help manage hair loss.
For polymorphous light eruption, phototherapy has improved symptoms for many patients. One study found that red and near-infrared light-emitting fabric could help with mild cases. However, PUVA (another type of light treatment) for skin conditions like psoriasis has been linked to a higher risk of skin cancer, though this risk is not related to the fabrics being tested.
Overall, while phototherapy is usually well-tolerated, following guidelines is important to minimize potential risks.12345Why are researchers excited about this trial?
Researchers are excited about the phototherapy garments for psoriasis because they offer a new, convenient way to manage the condition. Unlike standard treatments like topical creams, oral medications, or light therapy sessions that require visits to a clinic, these garments integrate phototherapy into everyday clothing. Made from Lumiton yarn, they deliver consistent light therapy simply by being worn indoors and outdoors. This innovative approach could potentially simplify treatment routines and improve patient adherence, making it a promising option for individuals seeking a more seamless way to manage their psoriasis.
What evidence suggests that this trial's phototherapy garments could be effective for psoriasis, alopecia areata, and polymorphous light eruption?
This trial will evaluate the effectiveness of phototherapy garments for various conditions. Research has shown that light therapy, or phototherapy, effectively treats psoriasis, with about 62% of patients experiencing at least a 75% improvement in their skin condition. In this trial, participants with psoriasis will wear sleeves made from Lumiton yarn.
For alopecia areata, studies have found that light therapies can significantly increase hair density and thickness. Participants with alopecia areata in this trial will wear a hat made from Lumiton yarn.
In the case of polymorphous light eruption, treatments like PUVA and UVB have demonstrated good or moderate improvements in 88-89% of patients. Participants with polymorphous light eruption in this trial will wear a shirt made from Lumiton yarn. This suggests that phototherapy can effectively manage outbreaks for many people.12678Who Is on the Research Team?
Joseph Jorizzo, MD
Principal Investigator
Wake Forest University Health Sciences
Are You a Good Fit for This Trial?
This trial is for adults over 18 living in the US with mild-to-severe Alopecia Areata, Polymorphous Light Eruption, or psoriasis. They must speak English well enough to understand the study requirements. People under 18, without these specific conditions, not living in the US, or using other phototherapy treatments cannot join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants wear Lumiton yarn garments daily for 12 weeks both indoors and outdoors
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Phototherapy
Trial Overview
The trial is testing Lumiton yarn products (sleeve, hat, shirt) designed to provide a form of light therapy for skin conditions like psoriasis and alopecia. The goal is to see if wearing these clothes can help improve disease severity by mimicking beneficial effects of UV light treatment.
How Is the Trial Designed?
3
Treatment groups
Active Control
Psoriasis participants will be provided sleeves made from the Lumiton yarn to cover their arms. The participants will be instructed to wear the sleeves made from Lumiton yarn daily for 12 weeks both indoors and outdoors.
Alopecia areata participants will be provided a hat made from the Lumiton yarn. The participants will be instructed to wear the hat made from Lumiton yarn daily for 12 weeks both indoors and outdoors.
Polymorphous light eruption participants will be provided a shirt made from the Lumiton yarn. The participants will be instructed to wear the shirt made from Lumiton yarn daily for 12 weeks both indoors and outdoors.
Phototherapy is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:
- Psoriasis
- Eczema
- Vitiligo
- Neonatal Jaundice
- Seasonal Affective Disorder
- Psoriasis
- Eczema
- Vitiligo
- Neonatal Jaundice
- Seasonal Affective Disorder
- Shift Work Disorder
- Psoriasis
- Eczema
- Vitiligo
- Neonatal Jaundice
- Seasonal Affective Disorder
- Psoriasis
- Eczema
- Vitiligo
- Neonatal Jaundice
- Psoriasis
- Eczema
- Vitiligo
- Neonatal Jaundice
- Psoriasis
- Eczema
- Vitiligo
- Neonatal Jaundice
- Seasonal Affective Disorder
Find a Clinic Near You
Who Is Running the Clinical Trial?
Wake Forest University Health Sciences
Lead Sponsor
Citations
1.
dermatologytimes.com
dermatologytimes.com/view/light-and-laser-therapy-is-an-effective-alternative-for-alopecia-treatmentLight and Laser Therapy is an Effective Alternative for ...
Light/laser therapies improve hair density and diameter in alopecia areata, androgenic alopecia, cicatricial alopecia, and telogen effluvium.
Three hundred and eight nanometer excimer light therapy ...
Three hundred and eight nanometer excimer light therapy has recently been reported to be effective against patchy alopecia areata (AA) in several clinical ...
Lasers in the management of alopecia: a review ...
The study's results indicated that NB-UVB phototherapy was effective for scalp AA during the 3-month treatment period. Patients in the NB-UVB ...
Phototherapy for alopecia areata
In this review, the author provides indications and therapeutic results of different wavelength phototherapy used in the treatment of alopecia areata (AA).
Efficacy and Safety of Laser Therapy and Phototherapy in ...
Overall, light/laser therapies exhibit a significant positive effect on increasing hair density and diameter across various alopecia types.
Photobiomodulation for the management of alopecia
Fifteen patients with patchy hair loss, were treated on some areas for 3 min once every 1 or 2 weeks for up to 5 months, while other areas acted as controls.
Based Therapies in the Treatment of Alopecia
Results: Of 403 articles identified, 63 were included based on relevance to alopecia or hair loss and light- based therapy. Results were ...
Full article: Could red and near-infrared emitting fabric ...
This pilot study assessed the efficacy of a red/near-infrared (NIR)-emitting fabric for psoriasis, polymorphous light eruption (PMLE), and alopecia areata (AA).
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