HMB + 2-HOBA for Aging
(H2AGE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
In this study, participants will be assigned to receive HMB, 2-HOBA, a combination of both, or a comparison supplement for a set period of time. During the study, participants will attend scheduled visits where researchers will assess muscle strength, physical function, and overall health. Blood samples may be collected to measure markers related to metabolism, inflammation, and oxidative stress. Study staff will also monitor safety and any side effects throughout the study.
Who Is on the Research Team?
Gustavo Duque, Medical Doctor
Principal Investigator
McGilll University Health Centre
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive HMB, 2-HOBA, a combination of both, or a placebo for 12 weeks. Muscle strength, physical function, and overall health are assessed. Blood samples may be collected to measure markers related to metabolism, inflammation, and oxidative stress.
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- 2-hydroxybenzylamine (2-HOBA)
- β-hydroxy-β-methylbutyrate and 2-hydroxybenzylamine
- β-hydroxy-β-methylbutyrate (HMB)
How Is the Trial Designed?
4
Treatment groups
Experimental Treatment
Placebo Group
Participants in the intervention group (H-2-H) will receive HMB + 2-HOBA (β-hydroxy-β-methylbutyrate and 2-hydroxybenzylamine and Cholecalciferol) at a dose of 3g and 650 mg/day, respectively, consisting of 2 tablets of 750mg and 325mg each, twice daily.
Participants in the intervention group (2-H) will receive 2-HOBA (2-hydroxybenzylamine and Cholecalciferol) at a dose of 650mg/day, respectively consisting of 2 tablets of 162.5mg each, twice daily.
Participants in intervention group HMB (H) will receive HMB supplementation (β-hydroxy-β-methylbutyrate and Cholecalciferol) at a dose of 3g/day, consisting of 2 tablets of 750mg each, twice daily.
Participants in control group (c) will receive 2 tablets- twice daily (Calcium Lactate and Cholecalciferol), each containing the same ingredients, placebo will be identical color and weight matched tablets with excipients (no HMB and no 2-HOBA).
Find a Clinic Near You
Who Is Running the Clinical Trial?
McGill University Health Centre/Research Institute of the McGill University Health Centre
Lead Sponsor
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