Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma
(FBE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The overall objectives of this BETRNet Research Center (RC) are:1. to conduct a rigorous, integrated spectrum of transdisciplinary human research in Barrett's esophagus (BE) and esophageal adenocarcinoma (ECA)2. to increase the biological understanding of key observations made by our clinical researchers;3. to translate knowledge derived from genetic, epigenetic, and transcriptome research to solving clinical dilemmas in detection, prognosis, prevention, and therapy of BE in order to prevent EAC and improve the outcomes of EAC;4. to foster a transdisciplinary and translation research culture and to effectively expand and enhance scientific research focused on BE and EAC;5. to evaluate research and transdisciplinary programs and to continuously improve research, productivity and enhance translational implementation. These objectives build and synergize on existing multi-institutional collaborative networks and the considerable clinical, basic science, and translational expertise available at our institutions, focusing on improving the outcomes of patients with BE and EAC. The overarching organization framework for this RC proposal is 1) to focus laboratory research on understanding the genetic susceptibility, genomic and epigenetic changes that influence the development of BE and EAC; and 2) to then translate laboratorydiscoveries into clinical applications for effective detection, molecular risk stratification, and prevention of progression from BE to EAC.
Who Is on the Research Team?
Amitabh Chak, MD
Principal Investigator
University Hospitals Cleveland Medical Center, CWRU, Cleveland, OH
Gary W Falk, MD, MS
Principal Investigator
University of Pennsylvania
William Grady, MD
Principal Investigator
Fred Hutchinson Cancer Research Center, UWMC, Seattle, WA
Nicholas J Shaheen, M.D.
Principal Investigator
University of North Carolina, Chapel Hill
Ganapathy Prasad, M.D.
Principal Investigator
Mayo Clinic
Marcia Canto, M.D.
Principal Investigator
Johns Hopkins University
John Dumont, D.O.
Principal Investigator
University Hospitals Cleveland Medical Center
Prashanthi Thota, M.D.
Principal Investigator
The Cleveland Clinic
Jean Wang, MD
Principal Investigator
Washington University School of Medicine
Julian Abrams, MD
Principal Investigator
Columbia University
Andrew Kaz, MD
Principal Investigator
VA Puget Sound Health Care System
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Esophageal Sampling
Participants undergo non-endoscopic balloon sampling and standard EGD for biospecimen collection
Treatment/Surveillance
Patients with BE or EAC undergo standard of care surveillance and diagnostic biopsies
Follow-up
Participants are monitored for safety and effectiveness after esophageal sampling
What Are the Treatments Tested in This Trial?
Interventions
- Endoscopy
Endoscopy is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:
- Diagnostic purposes for various gastrointestinal conditions including rectal cancer
- Diagnostic purposes for various gastrointestinal conditions including rectal cancer
- Diagnostic purposes for various gastrointestinal conditions including rectal cancer
- Diagnostic purposes for various gastrointestinal conditions including rectal cancer
- Diagnostic purposes for various gastrointestinal conditions including rectal cancer
- Diagnostic purposes for various gastrointestinal conditions including rectal cancer
Find a Clinic Near You
Who Is Running the Clinical Trial?
Case Western Reserve University
Lead Sponsor
University of North Carolina, Chapel Hill
Collaborator
The Cleveland Clinic
Collaborator
University of Pennsylvania
Collaborator
Columbia University
Collaborator
VA Puget Sound Health Care System
Collaborator
University Hospitals Cleveland Medical Center
Collaborator
Washington University School of Medicine
Collaborator
Fred Hutchinson Cancer Center
Collaborator
University of Washington
Collaborator