Adaptive Radiation Therapy for Pancreatic Cancer

Overseen By Joshua Meyer, MD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Fox Chase Cancer Center

Must not be taking: Chemotherapy, Immunotherapy

Disqualifiers: Metastatic disease, Prior radiation, Adenosquamous carcinoma, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 5

16 Participants Needed

Trial Summary

What is the purpose of this trial?

The goal of this clinical trial is to learn if Adaptive Radiation Therapy (ART) is safe and effective in treating patients with locally advanced pancreatic cancer. The main questions the study aims to answer are: * Can ART improve how well radiation therapy targets the most aggressive cancer cells, while protecting the healthy tissue around the tumor? * Can ART help reduce the side effects that participants may experience during treatment? Participants will: * Undergo CT scans to plan the exact location of the radiation treatment. During this process, 1-3 small markers may be placed in or near the tumor to help with the planning. * Have a tumor biopsy, which involves taking a small sample of tissue from the cancer. * Receive 5 radiation treatments every other day over a 2-week period. * Provide blood samples before, during, and after your radiation treatment.

Research Team

Joshua Meyer, MD

Principal Investigator

Fox Chase Cancer Center

Eligibility Criteria

This trial is for individuals with locally advanced pancreatic cancer that cannot be removed by surgery. Participants must be able to undergo CT scans, have markers placed in or near the tumor, provide a tissue sample from their cancer, and give blood samples before, during, and after radiation treatments.

Inclusion Criteria

I am a postmenopausal woman who has not had a period or breastfed in the last 12 months.

My pancreatic cancer cannot be removed by surgery.

I started chemotherapy before radiation, with my last chemo dose at least 2 weeks before starting ART.

Exclusion Criteria

I haven't had immunotherapy or antibody therapy in the last 28 days.

I am currently being treated for a serious infection with IV antibiotics.

My cancer is a type of pancreatic cancer called adenosquamous carcinoma.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Radiation

Participants undergo CT scans for planning, have tumor biopsies, and receive 5 radiation treatments every other day over a 2-week period

2 weeks

5 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment, including providing blood samples

4 weeks

Treatment Details

Interventions

• Adaptive Radiation Therapy

Trial Overview The study is testing Adaptive Radiation Therapy (ART) to see if it can more accurately target aggressive cancer cells while sparing healthy tissue. The treatment involves five radiation sessions every other day across two weeks with careful planning using CT scans.

Participant Groups

Group I: Single-Arm Experimental Treatment 1 Intervention

Adaptive Radiation Therapy

Who Is Running the Clinical Trial?

Fox Chase Cancer Center

Lead Sponsor

Trials

236

Recruited

39,300+