Investigational MRI Techniques for Imaging Assessment

Overseen By Michael V Knopp, MD, PhD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Cincinnati

Disqualifiers: Pacemaker, Claustrophobia, Pregnancy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

77 Participants Needed

Trial Summary

What is the purpose of this trial?

The goals of this study are to (1) develop and optimize MRI acquisition and post-processing techniques and (2) to generate preliminary and comparative data on sequences for potential clinical trials.

Research Team

Michael V Knopp, MD, PhD

Principal Investigator

Ohio State University

Eligibility Criteria

This trial is for adults who can safely undergo an MRI, including those already scheduled for a standard MRI at The Ohio State University. It's not suitable for individuals with metal implants, pacemakers, certain tattoos, or conditions that affect MRI safety; nor pregnant women, prisoners, or those unable to consent.

Inclusion Criteria

Patients receiving a standard of care 1.5 or 3T MRI at The Ohio State University

Healthy volunteers that feel comfortable receiving an investigational MRI

Exclusion Criteria

Participants who are pregnant, healthy volunteers

Participants with a contraindication to MRI. Such contraindications include, but are not limited to: pacemaker, metallic cardiac valve(s), magnetic material such as surgical clips, tattoos, implanted electronic infusion pumps or any other condition that would interfere with the MRI, a stent somewhere, a history of allergic reaction to any metals

I am unable to understand or sign the consent form.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Imaging Procedure

Participants undergo investigational MRI sequences in addition to standard of care imaging

Up to 2 hours per session

1 visit (in-person)

Data Analysis

Post-processing techniques are applied to MRI data for analysis

Ongoing throughout study

Follow-up

Participants are monitored for safety and effectiveness after imaging procedures

1-3 years

Treatment Details

Interventions

• MRI Scan - in addition to standard of care
• MRI Scan - not in addition to standard of care

Trial Overview The study is testing new ways of doing and processing MRI scans to improve the technique. Some participants will receive these investigational MRIs in addition to their standard care while others will get them separately.

Participant Groups

Group I: Patient population Experimental Treatment 1 Intervention

Group II: Healthy volunteer population Experimental Treatment 1 Intervention

Who Is Running the Clinical Trial?

University of Cincinnati

Lead Sponsor

Trials

442

Recruited

639,000+

Ohio State University

Lead Sponsor

Trials

891

Recruited

2,659,000+