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Transdermal Vagus Nerve Stimulation (tVNS) for Electroencephalography

N/A
Waitlist Available
Research Sponsored by Arkansas Tech University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up within single one hour session
Awards & highlights

Study Summary

This trial investigates whether electrical stimulation of the vagus nerve, applied at the ear, can change measures of the locus coeruleus' output: pupil diameter and EEG alpha power.

Who is the study for?
This trial is for healthy adults aged 18 or older. It's not suitable for those with mood disorders or who use stimulants, including everyday substances like caffeine and nicotine.Check my eligibility
What is being tested?
The study tests if non-invasive vagus nerve stimulation (tVNS) at the ear can change brain activity and pupil size, which could have implications for both science and potential treatments.See study design
What are the potential side effects?
Potential side effects of tVNS may include mild discomfort at the stimulation site, headache, lightheadedness, or temporary changes in heart rate or blood pressure.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~within single one hour session
This trial's timeline: 3 weeks for screening, Varies for treatment, and within single one hour session for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
EEG Alpha power.
Pupil Diameter

Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: Active Stimulation 0.5Experimental Treatment1 Intervention
0.5mA, 30Hz intermittent transdermal vagus nerve stimulation of the auricle vagus. Stimulation 30 second on/30 seconds off for five cycles.
Group II: NonstimulationPlacebo Group1 Intervention
Placement of electrode without any stimulation.
Group III: Sham StimulationPlacebo Group1 Intervention
0.5mA, 5Hz intermittent transdermal vagus nerve stimulation of the auricle vagus. Stimulation 30 second on/30 seconds off for five cycles.
Group IV: Lobe ControlPlacebo Group1 Intervention
0.5mA, 30Hz intermittent transdermal vagus nerve stimulation of the earlobe. Stimulation 30 second on/30 seconds off for five cycles.

Find a Location

Who is running the clinical trial?

Arkansas Tech UniversityLead Sponsor
1 Previous Clinical Trials
100 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are any new participants being accepted for this experiment?

"This medical trial, initially posted on September 1st 2020, is presently looking for participants. The data was most recently revised on March 2nd 2022 according to clinicaltrials.gov."

Answered by AI

How many participants are currently being welcomed into this trial?

"That is correct. Per the clinicaltrials.gov listing, this clinical trial is actively seeking applicants with a start date of September 1st 2020 and most recent amendment on March 2nd 2022. 55 individuals are required to be recruited at one site for completion of the study."

Answered by AI

Who else is applying?

What state do they live in?
Kansas
Arkansas
How old are they?
18 - 65
What site did they apply to?
Arkansas Tech University
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Testing the Noradrenergic Hypothesis of Transcutaneous Vagus Nerve Stimulation
2020. "Testing the Noradrenergic Hypothesis of Transcutaneous Vagus Nerve Stimulation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04455295.
~13 spots leftby Jun 2025
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