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Omega-3 Supplements for Cognitive Health in ApoE4 Carriers

N/A
Waitlist Available
Led By Melanie Plourde, PhD
Research Sponsored by Université de Sherbrooke
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Men and women aged between 30-50 years old
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 1, 2, 3, 4, 8 and 12 weeks after baseline
Awards & highlights

Study Summary

This trial will focus on understanding why clinical trials for cognitive decline prevention have not been successful in the past, in order to better design future trials.

Who is the study for?
This trial is for men and women aged 30-50 who are generally healthy. It's not for those with malnutrition, diabetes, chronic inflammation or immune conditions, cancer, recent major surgery or heart events, pregnant or breastfeeding women, pre/menopausal women, uncontrolled thyroid/renal/endocrine diseases, dementia sufferers, intense athletes or those with a history of severe substance abuse.Check my eligibility
What is being tested?
The study tests if new omega-3 fatty acid formulations can better reach the brain in people carrying the Apolipoprotein E Epsilon 4 allele. The goal is to see if these formulations improve cognition by increasing brain DHA concentrations compared to standard supplements.See study design
What are the potential side effects?
While specific side effects aren't listed here as it's a nutritional supplement trial rather than drug intervention; omega-3s may sometimes cause mild digestive discomfort or fishy aftertaste.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 30 and 50 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 1, 2, 3, 4, 8 and 12 weeks after baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 1, 2, 3, 4, 8 and 12 weeks after baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
DHA levels in LPC and FFA
EPA levels in LPC and FFA

Trial Design

2Treatment groups
Experimental Treatment
Group I: ApoE4 non carriersExperimental Treatment2 Interventions
The results obtained for APOE4 carriers will be compared to the one obtained from APOE4 non-carriers. Carriers are defined as being at least carrier of one APOE4 allele.
Group II: ApoE4 carriersExperimental Treatment2 Interventions
The results obtained for APOE4 carriers will be compared to the one obtained from APOE4 non-carriers. Carriers are defined as being at least carrier of one APOE4 allele.

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Who is running the clinical trial?

Université de SherbrookeLead Sponsor
292 Previous Clinical Trials
69,281 Total Patients Enrolled
Melanie Plourde, PhDPrincipal InvestigatorUniversité de Sherbrooke
2 Previous Clinical Trials
50 Total Patients Enrolled

Media Library

omega-3 phospholipids Clinical Trial Eligibility Overview. Trial Name: NCT04279743 — N/A
Healthy Subjects Research Study Groups: ApoE4 carriers, ApoE4 non carriers
Healthy Subjects Clinical Trial 2023: omega-3 phospholipids Highlights & Side Effects. Trial Name: NCT04279743 — N/A
omega-3 phospholipids 2023 Treatment Timeline for Medical Study. Trial Name: NCT04279743 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any inclusivity requirements for this clinical trial?

"The trial is currently looking for 160 individuals between the ages of 30 and 50 who match the characteristics of the healthy control group. The primary criteria for participation are as follows: being a man or woman aged 30-50 years old."

Answered by AI

Are investigators currently seeking new participants for this research?

"No, this particular study is not taking new patients. The trial was initially posted on August 1st, 2020 and was last updated 85 days ago. There are, however, 879 other trials that are still recruiting patients."

Answered by AI

Will this clinical trial recruit patients who are octogenarians?

"This trial's enrolment requirements state that potential participants must between 30 and 50 years old."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Fatty Acid Metabolism in Carriers of Apolipoprotein E Epsilon 4 Allele: Determining the Blood-to-brain Link
Mélanie Plourde 2020. "Fatty Acid Metabolism in Carriers of Apolipoprotein E Epsilon 4 Allele: Determining the Blood-to-brain Link". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04279743.
~31 spots leftby Apr 2025
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