Omega-3 Supplements for Cognitive Health in ApoE4 Carriers
Trial Summary
What is the purpose of this trial?
In Canada, \~17 millions of adults between 30-64 y old could benefit from a prevention strategy to lower the risk of Alzheimer's disease (AD). Although a lot of epidemiological studies reported positive cognitive outcomes in populations eating fish, there is skepticism about the link between docosahexaenoic acid (DHA), an omega-3 (OM3) fatty acid in fish and prevention of cognitive decline. This is largely because there is a disconnect between epidemiological, molecular and animal studies which generally favor a link between higher DHA intake and cognition whereas clinical DHA and fish oil trial seem not to support such as link. There are several knowledge gaps in this field that might explain why clinical trials were not successful. This project will focus on two major gaps : OM3 fatty acid metabolism and the blood-to-brain DHA link. OM3 supplements in cardiovascular disease have faced the same issues for decades but the more recent trials have now generated the clinical evidence supporting primary and secondary cardiovascular events reduction and a better risk to benefit balance of OM3 drugs compared to statins, for instance. What if, for cognitive decline, the target was missed because the supplement/drug formulations were not appropriately designed to target the brain? The investigators hypothesize that (i) E4 carriers display a faulty packaging of circulating OM3, leading to reduced bioavailability for brain cells, (ii) The use of new OM3 formulation can direct plasma DHA into brain compartments more readily available for the brain, thereby increasing brain DHA concentrations and improving cognition. Studies in mice and humans will be performed to test OM3 metabolism and the blood-to-brain DHA link. Ultimately the information generated in this research project will help to better design clinical trials in term of fatty acid formulation, expected level to reach in the plasma and the brain.
Research Team
Melanie Plourde, PhD
Principal Investigator
Université de Sherbrooke
Eligibility Criteria
This trial is for men and women aged 30-50 who are generally healthy. It's not for those with malnutrition, diabetes, chronic inflammation or immune conditions, cancer, recent major surgery or heart events, pregnant or breastfeeding women, pre/menopausal women, uncontrolled thyroid/renal/endocrine diseases, dementia sufferers, intense athletes or those with a history of severe substance abuse.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive new OM3 formulation to test OM3 metabolism and the blood-to-brain DHA link
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- omega-3 phospholipids
- omega-3 Triglycerides
Find a Clinic Near You
Who Is Running the Clinical Trial?
Université de Sherbrooke
Lead Sponsor