Low-Dose PET/CT Imaging Techniques
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests new methods to reduce radiation exposure during PET/CT scans, commonly used to detect medical issues like cancer. It compares a regular radiation dose with several lower doses (2.5 mCi, 5 mCi, 6.5 mCi, and 13 mCi) to determine if the images remain clear enough for doctors. Participants will undergo two scans about a week apart. Those scheduled for a standard PET/CT scan and comfortable lying still for a period are well-suited for this trial. As an unphased trial, it offers an opportunity to contribute to safer imaging practices.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that these low-dose PET/CT imaging techniques are safe?
Research has shown that low radiation dose PET/CT scans are generally safe. Studies have found that these scans emit less radiation compared to other medical imaging methods. For example, a typical whole-body PET/CT scan has a radiation dose of about 7 mSv, which is considered low.
Evidence also indicates that these scans can be adjusted to maintain high image quality while reducing radiation exposure. This adjustment allows patients to receive necessary diagnostic information with less radiation risk.
Overall, studies report that low-dose PET/CT scans are well-tolerated, with no significant side effects. They are designed to be both safe and effective, offering a safer option for those needing medical imaging.12345Why are researchers excited about this trial?
Researchers are excited about these low-dose PET/CT imaging techniques because they aim to reduce radiation exposure while maintaining image quality. Traditional PET/CT scans often use higher levels of radiation, which can pose risks, especially with repeated scans. This trial explores a range of reduced radiation doses, which could make PET/CT scans safer for patients by minimizing radiation without sacrificing diagnostic accuracy. By using advanced systems like the Biograph mCT and Vereos 128 digital PET/CT, the study seeks to identify the optimal balance between low radiation and high-quality imaging, potentially setting new standards for safer diagnostic practices.
What evidence suggests that these low-dose PET/CT imaging techniques could be effective?
This trial will compare different PET/CT scan radiation doses to evaluate their effectiveness in maintaining image quality. Studies have shown that PET/CT scans can use varying radiation doses without losing image quality. Specifically, research indicates that the 13 mCi dose can be halved while still performing well, particularly for cancer imaging. Studies found that the 2.5 mCi dose can be reduced by 66% without affecting the scan's clarity or accuracy. The 5 mCi dose remains effective for whole-body imaging without losing quality. Results for the 6.5 mCi dose demonstrate that a significant reduction is possible while maintaining good image quality. These findings suggest that lower doses can still provide effective imaging, reducing radiation exposure for patients.678910
Who Is on the Research Team?
Michael V Knopp, MD, PhD
Principal Investigator
Ohio State University
Are You a Good Fit for This Trial?
This trial is for adults over 18 who are scheduled for a standard PET/CT scan and can lie flat during the procedure. Women able to have children must meet specific requirements for imaging agents and CT exams. Pregnant or breastfeeding individuals, prisoners, or those unable to consent are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo PET/CT scans with both standard and low FDG doses for comparison
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- PET/CT scan with 13 mCi radiation dose
- PET/CT scan with 2.5 mCi radiation dose
- PET/CT scan with 5 mCi radiation dose
- PET/CT Scan with 6.5 mCi radiation dose
- PET/CT Scan with not yet determined radiation dose
Trial Overview
The study is testing new low-dose radiation techniques for PET/CT scans by comparing them with the current standard dose. Each participant will receive both a standard dose scan and one of several lower doses within one week.
How Is the Trial Designed?
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Treatment groups
Experimental Treatment
Patients receive PET/SCAN using system that did not show equivalence in Sub-Study A-C
Patients receive lower radiation dose on Vereos 128 digital PET/CT
Patients receive PET/CT scan on Vereos 128 digital PET/CT
Patients receive PET/CT scan on Discovery PET/CT
Patients receive PET/CT scan on Biograph mCT
Patients receive PET/CT scan on Gemini Astonish PET/CT
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Cincinnati
Lead Sponsor
Ohio State University
Lead Sponsor
Ohio Third Frontier
Collaborator
National Cancer Institute (NCI)
Collaborator
Citations
Performance and application of the total-body PET/CT ...
The total-body PET/CT system enables high-resolution whole-body imaging, even under extreme conditions such as ultra-low dose, extremely fast imaging speed.
Validation of true low-dose 18F-FDG PET of the brain - PMC
These studies included a low-dose CT with an average effective dose of 0.07 mSv (Dose length product 12-15 mGycm), so the total effective doses were 4.54 mSv ...
PET/MRI Versus PET/CT for Whole-Body Staging
The estimated mean effective dose for whole-body PET/CT amounted to 17.6 ± 8.7 mSv, in comparison to 3.6 ± 1.4 mSv for PET/MRI, resulting in a ...
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cancerimagingjournal.biomedcentral.com
cancerimagingjournal.biomedcentral.com/articles/10.1186/s40644-016-0086-0A method to assess image quality for Low-dose PET
Lowering injected dose will have an effect on PET image quality. In this article, we aim to investigate this effect in terms of ...
Advantages and Challenges of Total-Body PET/CT at a ...
Low-Dose Injection of PET Imaging Agents. The high sensitivity, along with a dramatically improved signal-to-noise ratio, of the total-body PET/ ...
Validating Low FDG Dose PET/CT Compared to Current ...
The purpose of this study is to assess new low radiation dose techniques for clinical PET/CT scans through intra-individual comparison between a clinical, ...
Optimizing Low-Dose [18F]FDG-PET/CT Scans
To optimize low-dose 18F-FDG scan protocols while maintaining high image quality despite radiotracer availability challenges. Materials and ...
Artificial Intelligence enables whole body Positron ...
Integrated 18F-FDG PET/MRI saves radiation by replacing CT with radiation free MRI scans (1). This addresses the radiation exposure from CT ...
Are PET CT Scans Dangerous? Risks, Safety, and Benefits ...
A common concern about PET CT scans is radiation exposure. However, the radiation dose from a PET CT scan is relatively low compared to other medical ...
Radiation protection of patients during PET/CT scanning
The radiation dose from such a scan can be low (e.g. an effective dose of about 7 mSv for a whole body study). However, the effective dose from a high ...
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