This trial is evaluating whether Botox will improve 3 primary outcomes and 12 secondary outcomes in patients with Chronic Exertional Compartment Syndrome. Measurement will happen over the course of baseline and month 2.
This trial requires 10 total participants across 1 different treatment group
This trial involves a single treatment. Botox is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 4 and have been shown to be safe and effective in humans.
"Surgical intervention can be successful in treating compartment syndromes. For this reason, a diagnosis of compartment syndrome should be considered a surgical emergency and it is recommended that a compressive dressing be applied as soon as possible. Early surgical intervention may be recommended in any case of compartment syndrome, due to the higher likelihood of successful management." - Anonymous Online Contributor
"There is an emerging body of evidence to strongly suggest that compartment syndrome is a pathophysiological mechanism for the development of compartment syndrome. A number of hypotheses have been presented to account for these findings, including decreased blood flow to areas exposed to increased pressures generated during increased compression. However, the results of animal studies have raised serious doubts as to how the development of compartment syndrome can be explained in this manner. If the evidence of animal models is correct, the mechanisms involved would represent novel mechanisms for why patients with deep venous disease develop compartment syndrome." - Anonymous Online Contributor
"Compartment syndromes can have a long-lasting effect on the patient's mobility. When these problems become evident, an appropriate diagnosis must be obtained early and an appropriate treatment must be prescribed early in the course of the disease." - Anonymous Online Contributor
"Compartment syndrome is a constellation of symptoms due to ischemia of tissue caused by compression by surrounding edema and is characterized by decreased perfusion (relative hyperemia) in a specific region of the extremity. This occurs in various settings and may range from mild symptoms, to life-threatening symptoms." - Anonymous Online Contributor
"The lack of consensus and the small number of reported cases in the literature makes the signs of compartment syndrome difficult to identify. Most cases of compartment syndrome are associated with trauma and therefore are not indicative of compartment syndrome. Most of the signs of compartment syndrome are" - Anonymous Online Contributor
"The number of cases of compartment syndrome that happen at the level of the thigh in the United States is less than 1% of cases per year. The most common cause of this condition is a leg injury. In the United States, compartment syndrome affects 3% of leg injuries." - Anonymous Online Contributor
"The leading causes of compartment syndromes are venous insufficiency and acute limb ischemia because of a chronic disease. Although both disorders are common, only when combined can predispose a patient to compartment syndrome." - Anonymous Online Contributor
"Although botox injection is well tolerated, there were no significant correlations between botox injection and any HRQOL or symptom severity in participants with CS after 12 weeks." - Anonymous Online Contributor
"The average age at presentation of patients with compartment syndromes is 56 years old, and the average age of a new patient was 51 years old. The highest percentage of men (82%) in the study were older than 53 years." - Anonymous Online Contributor
"Botulinum toxin should be considered whenever appropriate in the treatment of compartment syndrome. The clinical trial database provides a comprehensive list of botulinum toxin product usage in patients with compartment syndrome. We could not determine the usage of bcl toxin in patients with compartment syndromes because of the lack of available evidence." - Anonymous Online Contributor
"It is important to define the definition of compartment syndrome as some definitions omit compartment syndrome as of primary concern. Further research is necessary to elucidate how to define compartment syndrome and how to reduce the risk of compartment syndrome." - Anonymous Online Contributor
"For many patients, compartment syndromes can be treated safely and effectively via fasciotomy without any permanent impairment of limb function. For some patients, however, the condition is so severe that amputation is the only option in which limb is saved and in which patient functional impairment is minimal." - Anonymous Online Contributor