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Prazosin for Cannabis Use Disorder (ReCOUP Trial)
ReCOUP Trial Summary
This trial will study whether the drug prazosin, which is used to treat symptoms of PTSD, can also help reduce cannabis use disorder in people who have PTSD.
ReCOUP Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowReCOUP Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2016 Phase 1 trial • 20 Patients • NCT01999530ReCOUP Trial Design
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Who is running the clinical trial?
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- You have had an allergic reaction or a bad reaction in the past to prazosin or other similar medications.I am in good overall health.You are experiencing severe emotional distress or crisis, including suicidal or homicidal thoughts.I have had a moderate or severe brain injury in the past.You are generally healthy.I am not pregnant, planning to become pregnant, or nursing during the study.I will stop taking trazodone for 2 weeks before starting the study.You have used any drug other than cannabis, tobacco, or alcohol in the last 30 days.I am of any gender, race, or ethnicity.I am between 18 and 80 years old.I am of any gender and ethnic background.You have had a problem with using drugs or alcohol, except for cannabis or tobacco, within the past three months.You have a condition that affects your ability to think clearly or remember things accurately.I have severe sleep apnea that has not been treated.I am between 18 and 80 years old.I have used synthetic cannabinoids like Spice or K2 in the last 30 days.I can complete health assessments in English.
- Group 1: Open-label prazosin treatment
- Drug Has Already Been Approved - The FDA has already approved this drug, and is just seeking more data.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What other research has been performed on Prazosin Hydrochloride?
"Currently, 7 clinical trials are underway exploring the efficacy of Prazosin Hydrochloride. Of these studies, 1 is in Phase 3. While most experiments for this medication occur in Seattle Washington, there are 9 total sites running relevant research projects."
Does this research project permit participation from individuals under 25 years of age?
"The age range for participants in this trial is between 18 and 80. As expected, there are fewer trials available for those below the legal age of consent (298) when compared to individuals aged 65 or above (906)."
What is the common application for Prazosin Hydrochloride?
"Prazosin Hydrochloride is prescribed to address post traumatic stress disorder (PTSD). It may also be helpful in managing hypertension, disturbing dreams and benign prostatic hyperplasia (BPH)."
What is the upper limit on participants for this clinical trial?
"Affirmative. Clinicaltrials.gov records indicate that this trial, which was originally published on November 9th 2020, is currently recruiting participants. Twenty individuals are required between a single medical site."
Are researchers currently accepting new participants for this research endeavor?
"Affirmative. The details on clinicaltrials.gov specify that this scientific experiment, which was first shared 11/9/2020, is currently enrolling volunteers. This project requires 20 participants from a single medical facility to be recruited for the trial."
What are the eligibility requirements to be part of this experimental research?
"This clinical trial is searching for 20 individuals, aged between 18 and 80, who have experienced stress disorders or trauma. Furthermore, the study welcomes males, females and all racial backgrounds; provided they are in good health overall."
What potential adverse effects can arise from taking Prazosin Hydrochloride?
"Data collected from Phase 4 trials indicates that Prazosin Hydrochloride is safe, granting it a rating of 3."
Who else is applying?
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What portion of applicants met pre-screening criteria?
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