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Antibiotic

Vancomycin for Spinal Disorders

Phase 4
Recruiting
Led By Mohamed Soliman, MD
Research Sponsored by Windsor-Essex Compassionate Care Community
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients requiring surgery due to any spine disease
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 months
Awards & highlights

Study Summary

This trial will help researchers determine whether intra-wound vancomycin powder is effective in reducing post-surgical infection rates in spine surgery patients.

Who is the study for?
This trial is for patients needing surgery for any spinal disease. It aims to see if applying vancomycin powder into the surgical wound can prevent infections after spine surgery.Check my eligibility
What is being tested?
The study is testing whether intrawound vancomycin powder reduces post-surgical infections in spine surgeries. Patients are randomly assigned to receive either the vancomycin treatment or no treatment (control group).See study design
What are the potential side effects?
While not explicitly listed, potential side effects may include allergic reactions, irritation at the wound site, and possibly antibiotic resistance.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Rate of Infection
Secondary outcome measures
Complications

Trial Design

2Treatment groups
Active Control
Group I: VancomycinActive Control1 Intervention
For surgeries involving one level, 500mg of vancomycin will be applied. For surgeries involving greater than 1 level and less than 3 levels, 1gm will be applied and for surgeries greater than 3 levels, 2gms will be applied.
Group II: ControlActive Control1 Intervention
Participants will not be receiving vancomycin.

Find a Location

Who is running the clinical trial?

Windsor-Essex Compassionate Care CommunityLead Sponsor
3 Previous Clinical Trials
2,500 Total Patients Enrolled
Cairo UniversityOTHER
3,310 Previous Clinical Trials
1,541,859 Total Patients Enrolled
Mohamed Soliman, MDPrincipal InvestigatorWestern University
1 Previous Clinical Trials
400 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Orthopaedic SurgeryJournal
Effect of Intra-wound Vancomycin for Spinal Surgery: A Systematic Review and Meta-analysis
Xie, Lun-li, Jun Zhu, Mao-sheng Yang, Chang-yuan Yang, Shun-hong Luo, Yu Xie, and Dan Pu. 2017. “Effect of Intra-wound Vancomycin for Spinal Surgery: A Systematic Review and Meta-analysis”. Orthopaedic Surgery. Wiley. doi:10.1111/os.12356.
SpineJournal
Is Intraoperative Local Vancomycin Powder the Answer to Surgical Site Infections in Spine Surgery?
Hey, Hwee Weng Dennis, Desmond Wei Thiam, Zhi Seng Darren Koh, Joseph Shantakumar Thambiah, Naresh Kumar, Leok-Lim Lau, Ka-Po Gabriel Liu, and Hee-Kit Wong. 2017. “Is Intraoperative Local Vancomycin Powder the Answer to Surgical Site Infections in Spine Surgery?”. Spine. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/brs.0000000000001710.
European Spine JournalJournal
Intrawound Vancomycin to Prevent Infections After Spine Surgery: A Systematic Review and Meta-analysis
Evaniew, Nathan, Moin Khan, Brian Drew, Devin Peterson, Mohit Bhandari, and Michelle Ghert. 2014. “Intrawound Vancomycin to Prevent Infections After Spine Surgery: A Systematic Review and Meta-analysis”. European Spine Journal. Springer Science and Business Media LLC. doi:10.1007/s00586-014-3357-0.
The Spine JournalJournal
Reduced Surgical Site Infections in Patients Undergoing Posterior Spinal Stabilization of Traumatic Injuries Using Vancomycin Powder
O'Neill, Kevin R., Jason G. Smith, Amir M. Abtahi, Kristin R. Archer, Dan M. Spengler, Matthew J. McGirt, and Clinton J. Devin. 2011. “Reduced Surgical Site Infections in Patients Undergoing Posterior Spinal Stabilization of Traumatic Injuries Using Vancomycin Powder”. The Spine Journal. Elsevier BV. doi:10.1016/j.spinee.2011.04.025.
~1095 spots leftby Dec 2028
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