Lidocaine for Sympathetic Activity in Healthy Subjects
(SPARK Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The SPARK Study evaluates changes in peripheral sympathetic vasomotor activity following a targeted, ultrasound-guided periarterial sympathetic block of the distal radial artery in healthy volunteers. Autonomic reactivity will be assessed before and after the block using digit-specific pulse-amplitude index and infrared thermography during standardized cold pressor testing.
Who Is on the Research Team?
David MacLeod
Principal Investigator
Duke University
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Baseline measurements of pulse amplitude index and hand temperature are taken before any intervention
Intervention
Participants receive an ultrasound-guided periarterial sympathetic block of the distal radial artery
Post-Intervention Assessment
Measurements of pulse amplitude index and hand temperature are taken after the sympathetic block and during cold pressor testing
Follow-up
Participants are monitored for any delayed effects or adverse reactions following the intervention
What Are the Treatments Tested in This Trial?
Interventions
- Lidocaine
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Ultrasound-guided periarterial block with 2% lidocaine at right wrist.
Ultrasound-guided periarterial block with 2% lidocaine at left wrist.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Duke University
Lead Sponsor
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