Stannous Fluoride Toothpaste for Gum Disease
(ILIMSIR Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how a special toothpaste with stannous fluoride affects gum health and oral bacteria. Researchers aim to compare it to regular fluoride toothpaste, focusing on reducing gum inflammation and altering the oral microbiome. Ideal participants have at least 20 natural teeth and have not undergone a deep dental cleaning in the past three months. Those with serious gum issues or using certain medications are not eligible. The study seeks to enhance understanding of oral hygiene and may lead to improved toothpaste options for gum health. As a Phase 4 trial, this research involves an FDA-approved toothpaste, concentrating on its potential benefits for more patients.
What is the safety track record for Stannous Fluoride Toothpaste?
Research has shown that stannous fluoride toothpaste is safe for use. Studies have found that it helps prevent gum disease and cavities, and it reduces plaque and gum inflammation with regular use. These studies have reported no serious side effects, indicating that it is generally well-tolerated. This toothpaste performs as expected without causing harm, offering reassurance to those considering joining a clinical trial.12345
Why are researchers enthusiastic about this study treatment?
Unlike the standard fluoride toothpastes that are commonly used for gum disease, stannous fluoride toothpaste stands out because it combines the benefits of fluoride with the unique properties of stannous ions. These stannous ions not only help in preventing cavities but also possess antibacterial properties that target the bacteria responsible for gum disease. Researchers are excited about this treatment because it offers a dual-action approach—protecting teeth while actively fighting gum disease—potentially leading to healthier gums and stronger teeth.
What is the effectiveness track record for Stannous Fluoride Toothpaste in treating gum disease?
Research has shown that stannous fluoride toothpaste, which participants in this trial may use, helps reduce gum disease. Studies have found it reduces plaque, a sticky layer that can cause gum swelling. One study demonstrated that using this toothpaste can reduce bleeding gums by up to 95%. Another study revealed benefits within two weeks of use. Overall, stannous fluoride toothpaste has proven effective in improving gum health and delaying gingivitis.16789
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Gingivitis Induction
Participants undergo gingivitis induction using a customized stent to prevent oral hygiene
Gingivitis Resolution
Participants resume oral hygiene to resolve gingivitis
Follow-up
Participants are monitored for changes in inflammation and oral microbiome
What Are the Treatments Tested in This Trial?
Interventions
- Stannous Fluoride Toothpaste
How Is the Trial Designed?
2
Treatment groups
Active Control
Regular fluoride toothpaste
Stannous fluoride containing toothpaste
Find a Clinic Near You
Who Is Running the Clinical Trial?
Colgate Palmolive
Lead Sponsor
Noel Wallace
Colgate Palmolive
Chief Executive Officer since 2019
MBA from Harvard Business School
Diana Haussling
Colgate Palmolive
Chief Marketing Officer since 2022
Bachelor's degree in Marketing
The University of Texas Health Science Center, Houston
Collaborator
Citations
Stannous Fluoride in Toothpastes: A Review of Its Clinical ...
The results show that clinically beneficial reductions in plaque levels could be observed from two weeks of using stannous fluoride toothpaste, ...
2.
greaterbostondentist.com
greaterbostondentist.com/blog/which-toothpaste-is-best-for-gum-disease-stannous-or-sodium-fluoride/Which toothpaste is best for gum disease prevention ...
The antimicrobial effect of stannous fluoride is effective at delaying the onset of gingivitis, but unfortunately it will happen eventually, ...
Stannous Fluoride Toothpaste for Gum Disease
This trial tests the effectiveness of two kinds of toothpaste with stannous fluoride against gum disease compared to regular toothpaste.
4.
placervilledentistry.com
placervilledentistry.com/oral-health/does-stannous-fluoride-prevent-gum-disease/Does Stannous Fluoride Prevent Gum Disease?
Stannous fluoride is a form found to have notably superior antibacterial properties, better inhibiting plaque development and the gum inflammation that causes ...
Effectiveness of stannous fluoride in treating gingivitis
Moreover, the utilize of stabilized SnF2 toothpaste was found to have a useful effect on diminishing dental calculus, plaque, gingivitis, ...
A 6-Month Randomized Controlled Trial to Measure the ...
The test SnF2 dentifrice showed statistically significant reductions in all plaque and gingivitis indices compared to baseline and to the ...
A randomised clinical study investigating efficacy of a ... - PMC
These results indicate that plaque and gingivitis-reducing benefits of 0.454% w/w stannous fluoride may be seen from 2 weeks' use.
A Study to Evaluate the Efficacy of a Stannous Fluoride ...
This study will also explore whether a CPC mouthwash used with a SnF2 toothpaste could provide benefits in plaque accumulation reduction and gingival health ...
Effects of stannous fluoride dentifrice on gingival health and ...
Dentifrices containing high bioavailable levels of stannous fluoride (SnF2) have proven effective for the treatment and prevention of gingivitis ...
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