Continuous Glucose Monitoring and Insulin for Ketosis-Prone Diabetes
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this study is to quantify day-to-day changes in blood glucose during treatment towards remission in ketosis-prone diabetes (KPDM) and describe them using a mathematical model of KPDM pathogenesis and remission.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is insulin safe for use in humans?
Research shows that various types of insulin, including insulin lispro and insulin detemir, have safety profiles comparable to regular human insulin. Studies have not found significant differences in adverse events or complications, indicating that these insulins are generally safe for use in humans.12345
How does the drug insulin differ from other treatments for ketosis-prone diabetes?
Insulin therapy for ketosis-prone diabetes is unique because it uses continuous glucose monitoring and a combination of fast-acting and long-acting insulin analogues to closely mimic natural insulin secretion, improving blood sugar control and reducing the risk of hypoglycemia (low blood sugar) compared to traditional insulin treatments.678910
What data supports the effectiveness of the drug Insulin, including Humulin R, Novolin R, and others, for treating ketosis-prone diabetes?
Research shows that insulin detemir (Levemir) is effective in maintaining blood sugar control with less risk of low blood sugar at night and less weight gain compared to other insulins. Additionally, insulin lispro (Humalog) and regular human insulin (Humulin R) have been studied for their effects on liver glucose production in type 1 diabetes, which is relevant for managing blood sugar levels.111121314
Who Is on the Research Team?
Priyathama Vellanki, MD, MS
Principal Investigator
Emory University
Are You a Good Fit for This Trial?
This trial is for individuals with ketosis-prone diabetes (KPDM), a condition where the body produces high levels of blood acids called ketones. Participants should be experiencing this for the first time or have a history of similar episodes but not on long-term insulin therapy.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive standard-of-care insulin therapy and continuous glucose monitoring from hospital discharge until insulin discontinuation
Follow-up
Participants are monitored for safety and effectiveness after treatment, focusing on remission duration
What Are the Treatments Tested in This Trial?
Interventions
- Insulin
Insulin is already approved in European Union, United States, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Emory University
Lead Sponsor