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Hydrocortisone for Memory Impairment
Study Summary
This trial will use hydrocortisone or placebo to study the effects of chronic corticosteroid exposure on memory and the hippocampus in both men and women.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I am either not using estrogen-based birth control, am menopausal, or have irregular periods.You have a history of having problems with drugs or alcohol.My depression is moderate to severe, but not very severe.I have a history of neurological disorders like seizures or Parkinson's.I am between 18-40 years old and my vision, with correction, is at least 20-40.My BMI is between 18.5 and 35.I am taking medication for depression or other mental health conditions.I have depression but no other major psychiatric conditions like bipolar or schizophrenia.You are currently having thoughts about hurting yourself or have tried to hurt yourself in the past year or more than once in your life.I have used corticosteroids for more than 12 weeks in my life or inhaled them in the last 28 days.I have a significant medical condition like cancer, heart disease, or diabetes.I am allergic to or cannot take hydrocortisone due to health reasons.
- Group 1: Depressed: Placebo, then Hydrocortisone
- Group 2: Depressed: Hydrocortisone, then Placebo
- Group 3: Healthy Controls: Hydrocortisone, then Placebo
- Group 4: Healthy Controls: Placebo, then Hydrocortisone
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Drug Has Already Been Approved - The FDA has already approved this drug, and is just seeking more data.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What is the participant count for this trial?
"Confirmed. According to clinicaltrials.gov, the trail was initially published on October 1st 2019 and has been updated most recently on February 17th 2022. It is actively searching for 188 participants across one site."
What other research has been undertaken in regards to Hydrocortisone Oral?
"Currently, 60 clinical trials are investigating the use of Hydrocortisone Oral with 20 in Phase 3. While New york City is home to a large portion of these studies, an expansive network of 3054 medical sites worldwide have some iteration of this investigation running."
Has the US Food & Drug Administration granted clearance for Hydrocortisone Oral?
"As Hydrocortisone Oral has been approved by the authorities, its safety rating is 3 on a scale of 1-3."
What ailments does Hydrocortisone Oral typically alleviate?
"Hydrocortisone Oral is primarily used to treat ulcerative colitis, but can also be employed for the management of various other ailments such as malignant neoplasms, varicella-zoster virus acute retinal necrosis and crohn disease."
Are there any open enrollment opportunities for this clinical trial?
"Affirmative. The information accessible on clinicaltrials.gov confirms that this research study, initially posted in October of 2019 and recently updated on February 17th 2022 is currently recruiting patients. 188 individuals have to be recruited from a single location for the trial's completion."
Are there any criteria that would bar someone from joining this research initiative?
"Eligible candidates for this medical trial must have hydrocortisone and be between 18 to 40 years old. A total of 188 participants will take part in the experiment."
Is senior participation accepted in this experimental protocol?
"The parameters for this research endeavour require that all participants be at least 18 years of age and not surpass 40."
Who else is applying?
What state do they live in?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
Why did patients apply to this trial?
What questions have other patients asked about this trial?
How responsive is this trial?
Average response time
- < 2 Days
Typically responds via
Most responsive sites:
- UT Southwestern Medical Center: < 48 hours
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