Evolutionary Tumor Board for Chronic Conditions
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new method for creating treatment plans for cancer patients without a cure. The Evolutionary Tumor Board (ETB), a special team, will review each patient's medical history and current treatment options to suggest new strategies. It targets individuals whose previous cancer treatments were not fully effective or whose cancer might recur. Participants should be open to trying new treatment plans and are expected to share their medical data over time. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, offering participants a chance to explore potentially effective new strategies.
Do I have to stop taking my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that the Evolutionary Tumor Board (ETB) is safe for patients?
Research has shown that the Evolutionary Tumor Board (ETB) approach holds great promise. This method involves experts collaborating to develop new treatment plans for cancer patients with no other options. Since the ETB focuses on planning rather than introducing new drugs or treatments, it does not present direct safety concerns like medication side effects.
However, the safety of any specific treatment suggested by the ETB depends on the treatment itself. The board generates ideas based on each patient's unique situation, so treatment safety can vary. Each proposed treatment has its own safety details based on previous studies or existing approvals.
In summary, participating in a trial with the ETB primarily involves sharing medical history with experts who will devise new treatment strategies. The safety of any specific treatment they recommend must be considered separately, based on that treatment's details.
Why are researchers excited about this trial?
Researchers are excited about the Evolutionary Tumor Board (ETB) because it offers a personalized approach to cancer treatment that differs from traditional methods. Unlike standard treatments that follow a one-size-fits-all model, the ETB examines each patient's clinical history, available therapeutic options, and outcome expectations to devise tailored strategies. This approach leverages evolutionary ideas to adapt treatments, potentially leading to more effective and targeted cancer therapies. By integrating detailed imaging and pathology, the ETB aims to uncover novel therapeutic strategies that could improve patient outcomes.
What evidence suggests that the Evolutionary Tumor Board (ETB) is effective for developing therapeutic strategies in patients without curative options?
Research has shown that the Evolutionary Tumor Board (ETB), which will review participants in this trial, holds promise for improving outcomes in cancer patients. The ETB employs a unique approach by involving experts such as mathematicians and evolutionary biologists to develop better treatment plans. Early results suggest this method can lead to more effective cancer management, particularly when standard treatments have failed. Studies also highlight the ETB's ability to customize treatments to fit each patient's needs, potentially leading to better results. Overall, the ETB represents a promising new approach to addressing challenging cancer cases.12345
Who Is on the Research Team?
Jingsong Zhang, MD
Principal Investigator
Moffitt Cancer Center
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Review by ETB
Participants' clinical history, available therapeutic options, and outcome expectations are presented to the Evolutionary Tumor Board (ETB) for strategy development
Follow-up
Participants are monitored for the development and implementation of therapeutic strategies
What Are the Treatments Tested in This Trial?
Interventions
- Evolutionary Tumor Board (ETB)
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Participants clinical history, available therapeutic options, and outcome expectations will be presented to the Evolutionary Tumor Board (ETB) along with images and pathology. Strategies and models will be presented regarding additional evolutionary ideas that can be applied.
Find a Clinic Near You
Who Is Running the Clinical Trial?
H. Lee Moffitt Cancer Center and Research Institute
Lead Sponsor
Citations
Feasibility of an Evolutionary Tumor Board for Generating ...
We present the concept of an Evolutionary Tumor Board (ETB) and report interim results from a prospective, non-interventional pilot study.
Treatment of evolving cancers will require dynamic decision ...
The ETB integrates the expertise of mathematicians and evolutionary biologists into the clinical decision support framework of a traditional tumor board, and ...
3.
aacrjournals.org
aacrjournals.org/cancerres/article/82/10_Supplement/PR010/696448/Abstract-PR010-Evolutionary-Tumor-BoardAbstract PR010: Evolutionary Tumor Board: Implementing ...
Early results from the ETB show great promise for improving patient outcomes in cancer using mathematical modeling and evolutionary therapy.
Generating Novel Therapeutic Strategies Based on ...
This study will evaluate the ability of a multidisciplinary group, the Evolutionary Tumor Board (ETB), to develop therapeutic strategies in ...
IMO9: Tumor Board Evolution
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