Molecular Diagnostics for Organ Transplantation
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to improve how doctors diagnose issues with kidney transplants. The usual method can sometimes be inaccurate, leading to incorrect treatments. The study tests a new system, the Integrated Diagnostic System, which combines different tests to provide a clearer picture of the transplant's status. People who have had a kidney transplant and need a biopsy (a small sample taken to check for problems) might be suitable for this trial. The goal is to ensure patients receive the right treatment based on more accurate information. As a Phase 2 trial, this research measures how well the new system works in an initial, smaller group of people, offering participants a chance to contribute to advancements in kidney transplant care.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this Integrated Diagnostic System is safe for kidney transplant diagnostics?
Research has shown that diagnostic tools like the Integrated Diagnostic System, which combines molecular data and tissue studies, are generally safe and well-tolerated. These tools analyze information to improve diagnostic accuracy without introducing new drugs or treatments into the body, thus posing a low risk of harm to patients.
No specific side effects have been reported from using the diagnostic system itself. The primary goal is to enhance diagnostic accuracy, helping to avoid unnecessary treatments. This is especially important for patients with kidney transplants. The system aims to enhance safety by reducing unnecessary treatments and improving patient care.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores using microarrays in organ transplantation, which could revolutionize how we diagnose and treat transplant patients. Unlike traditional methods that rely heavily on biopsies and blood tests to monitor organ health, this integrated diagnostic system uses advanced microarray technology. This approach allows for more precise and personalized monitoring of the immune response to transplants. By detecting potential organ rejection earlier and more accurately, the method promises to improve patient outcomes and reduce the need for invasive procedures.
What evidence suggests that this Integrated Diagnostic System is effective for kidney transplant diagnostics?
Research has shown that combining different diagnostic methods improves diagnostic accuracy, leading to better patient outcomes. The new Integrated Diagnostic System, studied in this trial, combines molecular data, tissue change analysis, and clinical information to diagnose kidney transplant issues more precisely. Studies indicate that these combined approaches can quickly identify the right treatments, adjust them when necessary, and stop them if they aren't effective. This accuracy aids doctors in making better decisions, enhancing care for transplant patients. Overall, integrated diagnostics can greatly improve treatment for patients after organ transplants.678910
Who Is on the Research Team?
Philip F Halloran, MD PhD
Principal Investigator
University of Alberta
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Biopsy Collection and Analysis
Collection and molecular phenotyping of kidney transplant biopsies for clinical indications
Follow-up
Follow-up data is collected to monitor the outcomes of the biopsy analysis
What Are the Treatments Tested in This Trial?
Interventions
- Integrated Diagnostic System
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Alberta
Lead Sponsor
Citations
Integrated diagnostics: the future of laboratory medicine? - PMC
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insightsimaging.springeropen.com
insightsimaging.springeropen.com/articles/10.1186/s13244-023-01379-9Integrative diagnostics: the time is now—a report from the ...
Enormous recent progress in diagnostic testing can enable more accurate diagnosis and improved clinical outcomes.
Integrative Diagnostics: The Time Is Now—A Report From ...
Integrative diagnostics has the potential to identify correct therapies more quickly, modify treatment when appropriate, and terminate treatment when not ...
Diagnostic tests - Improving Patient Outcomes
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Evaluate PHM as an Integrated System Capability
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Safety Device Diagnostics - Pilz US
The Safety Device Diagnostics (SDD) enable you to call up extensive diagnostic data on Pilz safety devices. Doing this will reduce service operations.
8.
bannerengineering.com
bannerengineering.com/us/en/products/technologies/ISD.html?srsltid=AfmBOoo_KAasWiVIjXsLjaEj2GOwD6KTl6n8TqRqtfjTbBNCuhZY7JgqIn-Series Diagnostics
In-Series Diagnostics (ISD) makes it easy to access diagnostic data from devices in a safety system without special equipment or designated cabling.
Advancing safety analytics: A diagnostic framework for ...
Big data and analytics have shown promise in predicting safety incidents and identifying preventative measures directed towards specific risk variables.
Design of Intelligent Fault Diagnostic System (FDS)
This research work presents useful framework and mechanism for integrated fault diagnostic system, or FDS.
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