Chlorhexidine vs Calcium Hydroxide for Tooth Pain
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests two treatments, Chlorhexidine (an antiseptic) and Calcium Hydroxide, to determine which better alleviates tooth pain from apical periodontitis, a condition affecting the tip of the tooth root. The main goal is to assess whether 2% Chlorhexidine reduces pain more effectively between dental appointments compared to Calcium Hydroxide. Individuals experiencing tooth pain when biting due to apical periodontitis, who need a root canal, and can speak English or Spanish might be suitable for this study. As a Phase 3 trial, it represents the final step before FDA approval, offering participants the opportunity to contribute to the development of a potentially new standard treatment for tooth pain.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot have taken pain medication or antibiotics in the past 3 days before joining.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that chlorhexidine is generally safe for oral use. It often treats gum diseases and reduces swelling and redness. Some studies indicate it can cause mild side effects, such as tooth staining or changes in taste, especially with prolonged use. These side effects are usually not serious and can be managed.
Calcium hydroxide is also commonly used in dental treatments. Most people tolerate it well, though it can sometimes cause mild discomfort or irritation in the treated area. Overall, previous research and common dental practices consider both chlorhexidine and calcium hydroxide safe for dental use.12345Why do researchers think this study treatment might be promising for tooth pain?
Researchers are excited about using chlorhexidine for tooth pain because it offers a unique approach compared to standard treatments like over-the-counter pain relievers or antibiotics. Chlorhexidine is an antiseptic that targets bacteria directly in the mouth, which can help reduce inflammation and pain more effectively at the source. Unlike other treatments that may take longer to show results, chlorhexidine's antibacterial properties can potentially provide quicker relief by addressing the underlying causes of tooth pain.
What evidence suggests that Chlorhexidine and Calcium Hydroxide could be effective for reducing tooth pain?
This trial will compare Chlorhexidine and Calcium Hydroxide for tooth pain. Research has shown that chlorhexidine improves oral health. Studies have found that chlorhexidine significantly reduces signs of gingivitis, a gum swelling often caused by bacteria. Chlorhexidine also proves more effective than regular dental cleaning in enhancing oral health. For periodontitis, a gum infection, chlorhexidine reduces symptoms. Conversely, calcium hydroxide is frequently used in dental treatments for its ability to neutralize acids and protect teeth. While both offer benefits, direct comparisons between them in this context are still under investigation in this trial.16789
Who Is on the Research Team?
Rafael Roges, D.D.S.
Principal Investigator
Director, Advanced Endodontics
Are You a Good Fit for This Trial?
This trial is for adults over 18 with symptomatic apical periodontitis who need root canal therapy and can consent to treatment. Participants must speak English or Spanish, have a restorable tooth, and not have taken pain medication or antibiotics in the past 3 days.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either 2% Chlorhexidine or Calcium Hydroxide as an intracanal medicament
Follow-up
Participants are monitored for pain perception and adverse events post-treatment
What Are the Treatments Tested in This Trial?
Interventions
- Calcium Hydroxide
- Chlorhexidine
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Southern California
Lead Sponsor