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Glucagon-like peptide-1 receptor agonist

semaglutide 2.4 mg for Obesity

Phase 3
Waitlist Available
Research Sponsored by Novo Nordisk A/S
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from baseline (week 0) to end of treatment (week 68)
Awards & highlights

Summary

This trial will test if semaglutide injections can help people with knee pain by reducing their weight and knee pain. Participants will be randomly given either semaglutide or another treatment. The study will last for an extended period and include regular check-ups. Semaglutide is used for weight loss and type 2 diabetes treatment, showing significant efficacy in weight reduction.

Eligible Conditions
  • Obesity

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from baseline (week 0) to end of treatment (week 68)
This trial's timeline: 3 weeks for screening, Varies for treatment, and from baseline (week 0) to end of treatment (week 68) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in WOMAC pain score
Change in body weight
Secondary outcome measures
Achieving body weight reduction greater than or equal to 10% (yes/no)
Achieving body weight reduction greater than or equal to 5% (yes/no)
Amount of allowed rescue analgesics used during wash out
+11 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: semaglutide 2.4 mgExperimental Treatment1 Intervention
Participants will receive semaglutide subcutaneous (s.c) 2.4 mg once-weekly as adjunct to a reduced-calorie diet and increased physical activity
Group II: semaglutide 2.4 mg (placebo)Placebo Group1 Intervention
Participants will receive semaglutide subcutaneous (s.c) placebo once-weekly as adjunct to a reduced-calorie diet and increased physical activity
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
semaglutide 2.4 mg
2021
Completed Phase 3
~410

Find a Location

Who is running the clinical trial?

Novo Nordisk A/SLead Sponsor
1,525 Previous Clinical Trials
2,419,329 Total Patients Enrolled
144 Trials studying Obesity
132,079 Patients Enrolled for Obesity
Clinical Transparency (Dept. 2834)Study DirectorNovo Nordisk A/S
3 Previous Clinical Trials
2,434 Total Patients Enrolled

Media Library

Semaglutide (Glucagon-like peptide-1 receptor agonist) Clinical Trial Eligibility Overview. Trial Name: NCT05064735 — Phase 3
Obesity Research Study Groups: semaglutide 2.4 mg, semaglutide 2.4 mg (placebo)
Obesity Clinical Trial 2023: Semaglutide Highlights & Side Effects. Trial Name: NCT05064735 — Phase 3
Semaglutide (Glucagon-like peptide-1 receptor agonist) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05064735 — Phase 3
Obesity Patient Testimony for trial: Trial Name: NCT05064735 — Phase 3
~104 spots leftby Sep 2025
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