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Glucagon-like peptide-1 receptor agonist

semaglutide 2.4 mg for Obesity

Phase 3
Waitlist Available
Research Sponsored by Novo Nordisk A/S
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from baseline (week 0) to end of treatment (week 68)
Awards & highlights

Study Summary

This trial is comparing the effect of semaglutide to a placebo on weight and pain in obese patients with knee pain. It will last for 1.5 years and has 14 clinic visits.

Eligible Conditions
  • Obesity

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from baseline (week 0) to end of treatment (week 68)
This trial's timeline: 3 weeks for screening, Varies for treatment, and from baseline (week 0) to end of treatment (week 68) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in WOMAC pain score
Change in body weight
Secondary outcome measures
Achieving body weight reduction greater than or equal to 10% (yes/no)
Achieving body weight reduction greater than or equal to 5% (yes/no)
Amount of allowed rescue analgesics used during wash out
+11 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: semaglutide 2.4 mgExperimental Treatment1 Intervention
Participants will receive semaglutide subcutaneous (s.c) 2.4 mg once-weekly as adjunct to a reduced-calorie diet and increased physical activity
Group II: semaglutide 2.4 mg (placebo)Placebo Group1 Intervention
Participants will receive semaglutide subcutaneous (s.c) placebo once-weekly as adjunct to a reduced-calorie diet and increased physical activity
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
semaglutide 2.4 mg
2021
Completed Phase 3
~410

Find a Location

Who is running the clinical trial?

Novo Nordisk A/SLead Sponsor
1,513 Previous Clinical Trials
2,414,622 Total Patients Enrolled
141 Trials studying Obesity
131,631 Patients Enrolled for Obesity
Clinical Transparency (Dept. 2834)Study DirectorNovo Nordisk A/S
3 Previous Clinical Trials
2,434 Total Patients Enrolled

Media Library

Semaglutide (Glucagon-like peptide-1 receptor agonist) Clinical Trial Eligibility Overview. Trial Name: NCT05064735 — Phase 3
Obesity Research Study Groups: semaglutide 2.4 mg, semaglutide 2.4 mg (placebo)
Obesity Clinical Trial 2023: Semaglutide Highlights & Side Effects. Trial Name: NCT05064735 — Phase 3
Semaglutide (Glucagon-like peptide-1 receptor agonist) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05064735 — Phase 3
Obesity Patient Testimony for trial: Trial Name: NCT05064735 — Phase 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are some of the key conditions that semaglutide 2.4 mg has been shown to improve?

"Semaglutide 2.4 mg is frequently used to help patients manage their weight over the long term. However, it can also be used as part of a treatment plan that includes a reduced-calorie diet, exercise, and managing at least one other weight-related condition."

Answered by AI

Can you please list any other investigations that have included semaglutide 2.4 mg?

"The first semaglutide 2.4 mg clinical trial was completed in 2018 at the Novo Nordisk Investigational Site. So far, 123 trials have been completed in total. There are currently 59 actively recruiting trials, with a large number of these studies taking place in Saint Louis, Missouri."

Answered by AI

Does this research differ from other similar investigations?

"Since 2018, semaglutide 2.4 mg has been the subject of clinical research with the first trial sponsored by Novo Nordisk A/S. The Phase 4 drug approval was received following the first study in 2018, which involved 1387 patients. As of now, there are 59 live studies being conducted for semaglutide 2.4 mg across 711 cities in 55 countries."

Answered by AI

Why did researchers start this clinical trial?

"The pharmaceutical company leading this study, Novo Nordisk A/S, has announced that the primary outcome will be change in body weight from the start of the study (week 0) to the end of treatment (week 68). Additionally, this trial will be measuring if patients achieve a 5% or greater reduction in body weight (yes/no), change in pain medication (dose), and change in WOMAC stiffness score (points)."

Answered by AI

What are the FDA's most recent thoughts on semaglutide 2.4 mg?

"Semaglutide 2.4 mg is in Phase 3 clinical trials, signifying that while there is efficacy data, there are also multiple rounds of safety data. Because of this, our team has given it a score of 3."

Answered by AI

Are there any available appointments for this clinical trial?

"This specific trial is not enrolling patients at the moment, as indicated by the clinicaltrials.gov website. The listing was created on October 1st, 2021 and was last edited June 21st, 2022. Even though this trial has closed recruitment, there are 1,754 other trials that are still recruiting patients."

Answered by AI

Who else is applying?

What state do they live in?
Missouri
New York
Other
California
How old are they?
65+
18 - 65
What site did they apply to?
Novo Nordisk Investigational Site
Other
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
2
0

Why did patients apply to this trial?

I want to contribute my knowledge and learn from others. I'm hoping this drug will help me with my weight loss goals.
PatientReceived 1 prior treatment
I have tried to lose weight, now I have painful joints. knees, legs and fingers. I take pain pills to relive my pain. I also have pre diabetes. Hoping I can help others with being part of this study.
PatientReceived no prior treatments

What questions have other patients asked about this trial?

How long do screening visits take and how many visits are involved in the study?
PatientReceived no prior treatments

How responsive is this trial?

Most responsive sites:
  1. Novo Nordisk Investigational Site: < 48 hours
Average response time
  • < 2 Days
Typically responds via
Email
Phone Call
~116 spots leftby Apr 2025