3500 Participants Needed

MET097 for Obesity

(VESPER-4 Trial)

Recruiting at 4 trial locations
MR
Overseen ByMetsera Recruiting
Age: 18+
Sex: Any
Trial Phase: Phase 3
Sponsor: Metsera
Pivotal Trial (Near Approval)This treatment is in the last trial phase before FDA approval
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

This study investigates the efficacy and safety of once weekly injectable MET097 in adult participants with obesity or overweight with weight-related comorbidities excluding T2D. This trial will last for a duration of 84 weeks. The primary endpoint will be assessed after 64 weeks of treatment with the secondary at 84 weeks.

Are You a Good Fit for This Trial?

Inclusion Criteria

My BMI is over 27 and I have a weight-related health issue like high blood pressure or heart disease.

Exclusion Criteria

Have any form of diabetes
I have lost or gained more than 11 pounds in the last 3 months.
I or my family have a history of MTC or MEN-2.
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Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive once-weekly injectable MET097 or placebo for 64 weeks

64 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

20 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • MET097

How Is the Trial Designed?

4

Treatment groups

Experimental Treatment

Placebo Group

Group I: MET097 Dose 3Experimental Treatment1 Intervention
Group II: MET097 Dose 2Experimental Treatment1 Intervention
Group III: MET097 Dose 1Experimental Treatment1 Intervention
Group IV: PlaceboPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Metsera

Lead Sponsor

Trials
3
Recruited
610+