60 Participants Needed

Image-Guided Radiosurgery for Brain Tumor

(IG-SRS Trial)

CC
SM
Overseen BySheila Medina
Age: 18+
Sex: Any
Trial Phase: Phase 2
Sponsor: Jona Hattangadi-Gluth
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial uses advanced imaging and precise radiation treatment to help adult patients with 1 to 3 brain metastases. It aims to protect important brain areas during treatment, preserving cognitive functions like memory and attention.

Who Is on the Research Team?

JH

Jona Hattangadi-Gluth, MD

Principal Investigator

University of California, San Diego

Are You a Good Fit for This Trial?

Adults over 18 with 1-3 small brain metastases from cancers like lung or breast, who can undergo MRI scans and have a life expectancy over 6 months. They must be able to perform daily activities with mild symptoms at most and participate in neurocognitive tests. Pregnant women, those unable to use contraception, or patients previously treated with whole brain radiation are excluded.

Inclusion Criteria

Willingness/Ability to undergo brain MRI scans
You have one to three small brain tumors, each less than 3 cm in size.
You are expected to live for at least 6 more months.
See 4 more

Exclusion Criteria

Pregnant or nursing women
Women of childbearing potential unwilling to use adequate contraception
You are not able to undergo a magnetic resonance imaging (MRI) scan with a contrast dye.
See 5 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Participants undergo MRI with DTI and 3D volumetric imaging and a battery of neurocognitive tests

1 week
1 visit (in-person)

Treatment

Participants receive cognitive-sparing brain SRS with advanced imaging techniques

1 week
1 visit (in-person)

Follow-up

Participants are monitored for cognitive performance and imaging biomarkers at 1, 3, and 6 months post-treatment

6 months
3 visits (in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • Cognitive Sparing Brain Stereotactic Radiosurgery (SRS)
Trial Overview The trial is testing a precise radiosurgery technique that aims to spare cognitive function while targeting brain tumors. It uses advanced imaging methods to protect critical brain areas during treatment and assesses the effectiveness through biomarkers of radiation response.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Image-guided cognitive sparing brain SRSExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Jona Hattangadi-Gluth

Lead Sponsor

Trials
2
Recruited
310+

National Cancer Institute (NCI)

Collaborator

Trials
14,080
Recruited
41,180,000+

National Institutes of Health (NIH)

Collaborator

Trials
2,896
Recruited
8,053,000+
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