This trial is evaluating whether Total-Body Irradiation will improve 1 primary outcome and 4 secondary outcomes in patients with Aplastic Anemia. Measurement will happen over the course of At 2 years post hematopoietic stem cell transplant (HSCT).
This trial requires 67 total participants across 2 different treatment groups
This trial involves 2 different treatments. Total-Body Irradiation is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
"The data suggest that TBI may be an effective therapy for systemic lupus erythematosus with certain clinical features such as a history of malignancy or presence of leukocytosis." - Anonymous Online Contributor
"Although TBI has been studied extensively since its introduction, recent advances in radiotherapy techniques have led to an increased interest in this modality for hematological malignancies. In particular, the use of TBI with busulfan and etoposide has proven effective in treating non-Hodgkin's lymphoma." - Anonymous Online Contributor
"Survival rates have improved significantly since the 1970s. The current paradigm is that remission rates should be achieved, and then maintenance therapy should be continued to keep relapse rates low. This approach has undoubtedly led to better overall survival rates. However, there is still much work to be done to understand why some patients do not respond to initial therapy, and why relapse rates remain high after remission is achieved." - Anonymous Online Contributor
"The data suggest that this regimen might be useful as salvage therapy after remission induction in patients who do not respond to initial treatments; the high response rate (50%) and excellent results make this approach especially attractive." - Anonymous Online Contributor
"Findings from a recent study showed that leukemic cells were able to travel through the blood stream at a rate similar to that of normal circulating leukocytes. Findings from a recent study indicate that this process may not be as rapid as previously thought." - Anonymous Online Contributor
"There are many studies on leukemia, lymphocytic, chronic, b-cell. It will be great if all these studies are published together into a single review by reputable journal to give more information about leukemia, lymphocytic, chronic, b-cell and other related conditions." - Anonymous Online Contributor
"Results from a recent paper suggest that the primary cause of leukemia, lymphocytic, chronic, b-cell is aging. No correlation was found between the age at diagnosis and the initial type, duration, or number of treatments of leukemia, though the duration of the disease did correlate with relapse." - Anonymous Online Contributor
"Furthermore, there was little evidence of the therapeutic value of TBI in CLL patients with BCR to autologous bone marrow transplantation. Findings from a recent study support the use of TBI only in patients with high-risk disease (i.e., blast crises or relapsing or refractory disease) or whose disease progresses following transplants. However, further studies are needed to identify the role of TBI in non-high-risk patients." - Anonymous Online Contributor
"[Lymphoma (lymphocytic, chronic, B-cell), myeloid leukemia, acute myeloid leukemia, and chronic myelogenous leukemia|chronic myelogenous leukemia]] are both difficult and risky to treat because of their similar nature, disease progression, and prognosis. The most effective treatment is chemotherapy plus either allogeneic stem cell transplantation or autologous stem cell transplantation. For patients who have already had a stem cell transplant, they cannot receive other types of treatments unless there is no evidence of relapse or graft versus host disease." - Anonymous Online Contributor
"Leukemia, lymphocytic, chronic, b-cell is a common name for multiple types of cancer including myeloid leukemia, acute and chronic leukemia, B-cell neoplasms, T-cell lymphomas, and Hodgkin disease. Please see schema below for more details." - Anonymous Online Contributor
"This pilot study indicates that TBI is safer than previously reported estimates. A larger prospective nonrandomized study should be performed to establish whether this observation has any implications for the use of TBI in patients with leukaemia." - Anonymous Online Contributor