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Reduced-Intensity Conditioning for Blood Cancers
Study Summary
This trial is looking at whether a less intense conditioning regimen of radiation therapy and chemotherapy prior to a hematopoietic stem cell transplant reduces the rate of treatment-related mortality.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- My liver is functioning well, based on recent blood tests.Your lung function is at least 50% of what it is expected to be for someone of your age and size.Your kidneys work well enough to filter at least 60 milliliters of waste from your blood every minute.I have a donor who is an exact match for my bone marrow transplant.I do not have any other cancer besides skin cancer that needs only local treatment.I have a blood-related cancer or condition and a partially matched donor.Your heart's pumping ability is at least 50%.You have HIV, cancer in the brain, or are pregnant or breastfeeding.I have a blood cancer or disorder and a partially matched donor for a transplant.
- Group 1: Radiation-Based Cohort (fludarabine, TBI, infusion)
- Group 2: Chemotherapy-Based Cohort (fludarabine, melphalan, TBI)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Has Hematopoietic Cell Transplantation been researched in other studies?
"Currently, 1056 Hematopoietic Cell Transplantation trials are in progress with 192 reaching the Phase 3 stage. Of those studies, many are based near Philadelphia, PA but there are over 30k clinical trial sites offering these treatments worldwide."
Has Hematopoietic Cell Transplantation been validated by the FDA?
"There is some evidence of the safety profile for Hematopoietic Cell Transplantation, so it has been given a score of 2."
Is there a window of opportunity to join this scientific experiment?
"The clinical trial hosted on clinicaltrials.gov is actively seeking candidates, with its initial posting being the 25th of October 2021 and its most recent edit taking place on April 1st 2022."
What conditions usually benefit from Hematopoietic Cell Transplantation?
"Hematopoietic Cell Transplantation has been authorised to treat a variety of medical conditions, such as dermatitis and atopic diseases, multiple sclerosis, acute myelocytic leukemia."
What is the participant count for this clinical research endeavor?
"Affirmative. According to information provided on clinicaltrials.gov, this trial is actively looking for participants and was initially posted on October 25th 2021. It was last updated April 1st 2022 and requires 67 volunteers from a single medical centre."
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