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Bone Marrow Transplant for Blood Cancers
Study Summary
This trial is testing a new way to do a bone marrow transplant using cells from a related donor. They will track how well patients do 18 months after the transplant.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I am mostly able to care for myself and carry out daily activities.My condition is related to natural killer cell malignancies.I have CML in the accelerated phase and TKIs haven't worked for me or I can't tolerate them.My leukemia is in remission.I am currently living with HIV.I agree to use birth control during the study if I or my partner can become pregnant.I have had a bone marrow transplant from a donor or my own within the last 6 months.My blood disorder is severe but with less than 5% cancer cells.My blood cancer has less than 5% blast cells, or I've had treatment to reduce it to this level.My Burkitt's lymphoma is in its second or later remission.My selected donor and I have undergone detailed HLA typing and share a HLA haplotype.My AML is in remission with less than 5% of cells being blasts.My lymphoma has returned after treatment, is responsive to chemotherapy, but I can't have a stem cell transplant.My T-cell lymphoma has returned but responds to chemotherapy and I can't have a stem cell transplant.My lymphoma has returned or not responded to treatment, and I've had at least two prior therapies.I have an active brain or spinal cord tumor.I am 55 or older, or I have significant health issues.I do not have a fully matched family donor for a transplant.You have a type of AML that is considered low risk according to the study's guidelines.My AML is considered low risk based on specific genetic features.My leukemia/lymphoma is in its second or more remission, or I had a bad reaction to initial treatment.I have an active brain or spinal cord tumor.My organs are working well.I currently have an infection that hasn't been treated.
- Group 1: Conditioning Regimen + Transplant
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What potential adverse side effects have been reported with Total Body Irradiation?
"Due to the nature of a Phase 2 trial, with some safety data present but no efficacy information, Total Body Irradiation was rated as a level 2 for safety."
How many people have enrolled in this trial?
"Unfortunately, this clinical trial closed its enrollment by August 12th 2022. However, there are 3350 separate studies recruiting patients with Burkitt lymphoma and 442 trials actively admitting participants for Total Body Irradiation treatment."
Is this research project enrolling participants at present?
"According to the clinicaltrials.gov website, this particular study has no open positions available at present; it was initially published on December 6th 2019 and last updated on August 12th 2022. Nonetheless, there are 3,792 other studies actively recruiting participants across the world today."
What kinds of conditions does Total Body Irradiation typically help to treat?
"Total Body Irradiation is a common treatment for chronic lymphocytic leukemia, as well as certain stem cell transplantations, amyloidosis cases, and various types of non-Hodgkin's lymphomas."
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