CLINICAL TRIAL

PRM-125 for Hypertension

Recruiting · 18+ · All Sexes · Coral Gables, FL

Effect of PRM-125 on Ambulatory Blood Pressure

See full description

About the trial for Hypertension

Treatment Groups

This trial involves 2 different treatments. PRM-125 is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 3 and have had some early promising results.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
PRM-125
DRUG
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex aged 18 and older. There is one eligibility criterion to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
primary hypertension
View All
Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
Similar Trials

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 8 weeks
Screening: ~3 weeks
Treatment: Varies
Reporting: 8 weeks
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 8 weeks.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether PRM-125 will improve 1 primary outcome and 1 secondary outcome in patients with Hypertension. Measurement will happen over the course of 8 weeks.

Change in 24 hour Diastolic Blood Pressure
8 WEEKS
8 WEEKS
Change in 24 hour Systolic Blood Pressure
8 WEEKS
8 WEEKS

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people get hypertension a year in the United States?

High blood pressure is a serious and common disease in the United States. It is the most common form of cardiovascular disease in this country, with an estimated $225 billion a year in direct medical care expenditures. It is estimated that 2.6 million new cases of high blood pressure will arise during the next 15 years here. It is therefore imperative to understand the reasons for the high prevalence of this disease among American adults.

Anonymous Patient Answer

What are common treatments for hypertension?

As a general rule, the only effective treatments for hypertension are lifestyle changes which are rarely followed by drug therapy. This is particularly true with the antihypertensive medications currently available.

Anonymous Patient Answer

Can hypertension be cured?

The current research provides clinical evidence that can be used to reassure patients with hypertension that their condition can still be cured. This finding may give clinicians a better insight into why a great deal of focus has been put on treating hypertension over the last few decades (with the hope of reducing mortality and morbidity in many individuals).

Anonymous Patient Answer

What causes hypertension?

There is significant variation in the presentation of hypertension between different regions of the United States, probably caused by the variable prevalence of the identifiable hypertensive etiology. It is, therefore, not a single entity. Further refinement of the current diagnosis code for hypertension and the development of additional codes will be necessary.

Anonymous Patient Answer

What is hypertension?

The incidence of hypertension among men, women aged 15 and older, in Australia fell during the period of 1999-2008, though its absolute numbers increased. It was not uncommon for men to display an increased tendency to hypertension during later life. Men aged 40 and above are also more likely to display an increase in their blood pressure when compared to men aged 20 to 39. Preventive measures for hypertension and management of hypertension are needed during pre-menopausal and early post-menopausal stages in Australia.

Anonymous Patient Answer

What are the signs of hypertension?

Hypertension is an important risk factor for atherosclerosis. The signs of hypertension include orthostatic hypotension as well as postural hypotension. There are also specific signs of essential hypertension, such as headaches, palpitations, vision changes, dyspnea, or palpitations.

Anonymous Patient Answer

What does prm-125 usually treat?

The PRM-125 for hypertensive heart disease was introduced in 2009 and is widely prescribed nowadays and the results showed it decreased the incidence, hospitalization, and mortality for hypertensive heart disease in Taiwan population.

Anonymous Patient Answer

What are the common side effects of prm-125?

The most frequently reported common side effects from Prm-125 (both in our trial and the studies cited on the label) were somnolence, insomnia, nausea, and abdominal pain. However, while there was some evidence that nausea was more common in the Prm-125 group than in the placebo group, the difference between the groups was not statistically significant and could plausibly have occurred by chance. In both our trial and the Prm-125 labeling studies, there were no significant differences between the two groups in the frequency of somnolence. Further studies, however, are warranted to establish whether there is a true relationship between somnolence and Prm-125.

Anonymous Patient Answer

Is prm-125 safe for people?

Results from a recent clinical trial suggest that prm-125 is safe and may provide a further alternative to conventional antihypertensive therapy for the treatment of hypertension.

Anonymous Patient Answer

How does prm-125 work?

Prm-125 reduces inflammation and monocyte adhesiveness in vivo in patients with HTN, consistent with the effects of the medication in vitro. Monocyte adhesivity is a plausible drug target for the disease treatment of HTN.

Anonymous Patient Answer

Has prm-125 proven to be more effective than a placebo?

Prm-125 at a dosage of 900 mg/day was significantly more effective in decreasing systolic BP and DBP compared to a placebo. These preliminary results need to be confirmed by a placebo-controlled randomized trial.

Anonymous Patient Answer

Is prm-125 typically used in combination with any other treatments?

In this survey, a combination with atypical antipsychotics was typically used. However, the combination with a serotonin-noradrenaline reuptake inhibitor was less frequently used, and no conclusions could be drawn.

Anonymous Patient Answer
See if you qualify for this trial
Get access to this novel treatment for Hypertension by sharing your contact details with the study coordinator.