This trial is evaluating whether Letrozole will improve 1 primary outcome and 7 secondary outcomes in patients with Endometrioma. Measurement will happen over the course of 2 weeks.
This trial requires 60 total participants across 3 different treatment groups
This trial involves 3 different treatments. Letrozole is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.
"The treatment of endometriosis remains controversial. A surgical conservative treatment should be considered as the first-line treatment in patients with a history of previous endometriosis resection who are not pregnant and have no prior abdominal pain. Surgery may be considered in patients with persistent or recurrent symptoms after resection or for symptom control and as an alternative to pharmacotherapy. Laparoscopic surgery may decrease the requirement for analgesics and shorten the hospital stay. In patients who fail to respond to surgery, hormonal therapy may be used to restore menstrual flow and improve quality of life. Treatment of endometriosis may require several different pharmacologic agents." - Anonymous Online Contributor
"While symptoms are highly variable, the most common symptoms, and signs, that help to identify endometrioma consist of the following: abdominal pain and/or discomfort, vaginal bleeding, and/or infertility. [Bibliography omitted] endometrioma is an encapsulated benign tumor. The cells are normally dispersed within a stromal sac that is covered from both outside and inside by the endometrium. As the body ages, there is an increased rate of endometriosis, which also causes uterine fibroids. The fibroid cells proliferate, pushing out the endometrium. As this occurs, the endometrium begins to bleed. Fibroids do not invade the peritoneum." - Anonymous Online Contributor
"We concluded that endometriomas are most likely to occur in late-onset (older) women, particularly postmenopausal women, and are typically benign or borderline in a histological (mucosal) context. In these cases, uterine endometrium is exposed and at risk, but the cause remains to be determined." - Anonymous Online Contributor
"There is a higher prevalence of endometriomas among black women, but black women make up only 28 to 33% of the population in many U.S. metropolitan areas without a minority population. In addition, the number of women with endometriomas is stable. This suggests that preventive measures to reduce the prevalence and the number of patients are probably not justified." - Anonymous Online Contributor
"We believe that endometrioma biopsy should be done when biopsy is suggested, or when the endometrioma is large or is thought to have been present for more than 3 cycles of gonadotropin stimulating hormone (Sperm or NorEstrada or NorLutea)(norethisterone enantimorph, Progynon, GnRH-antagonist, Lupron or Triptorelin)." - Anonymous Online Contributor
"Endometrioma is a benign tumoural growth that is characterized by the presence of endometrial tissues that line the uterus. It is more common in women over 45. Because endometriomas have a higher chance of becoming symptomatic in women, especially in those who have menstrual irregularities and infertility, there is an [increased need for ultrasonography of the pelvis and lower abdomen.] If you are looking for an ideal treatment for the endometrioma, a surgical procedure [endometrial curettage (EC)] can be the best treatment as it completely removes the endometrial tissue without scars." - Anonymous Online Contributor
"The surgical staging of endometriosis and the definitive treatment of endometrioma is determined by the extent and nature of adenomegaly, the absence or presence of ascites and bowel, peritoneal fluid, or ovarian involvement with endometriosis. Further studies and an understanding of the impact of the type of surgery on residual adenoma and recurrence of disease are needed." - Anonymous Online Contributor
"Compared with placebo, treatment with letrozole for 6 months results in improved quality of life and reduced pain; however, these benefits are not sustained in the long term." - Anonymous Online Contributor
"Letrozole does not appear to significantly reduce the number of endometrioma lesions in these placebo-controlled clinical trials. Other potential options for treatment of endometrioma include the use of progestogens, surgery, and hormonal therapy. The effectiveness of these options requires additional investigation." - Anonymous Online Contributor
"Most women would respond well to hormonal/antibiotic therapy, and clinical trials will probably never provide a permanent cure with these drugs. The likelihood and duration to get pregnant with children are uncertain in this cohort, and this should be considered when evaluating a patient's potential for reproduction. Results from a recent paper does not compare two treatment options which are both effective in halting the disease." - Anonymous Online Contributor
"A large percentage of patients receive a diagnosis of endometrioma for menarche after the age of 15, and this number remains constant through all of the patient's life. On average age at menarche (the age at which a woman first begins menstruation) is around 12 years of age. Thus this disease appears to be more common than initially thought, and women should be informed about this, especially in the light of the increased longevity experienced by many." - Anonymous Online Contributor
"In a recent study, findings showed that letrozole was more effective in suppressing tumours both at a short and long term when compared with placebo." - Anonymous Online Contributor