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Brushing Regimens for Gum Disease

Age: 18+
Sex: Any
Trial Phase: Phase 3
Sponsor: Colgate Palmolive
Must not be taking: Antibiotics, Prescription medicines
Disqualifiers: Orthodontic appliances, Partial dentures, Tumors, Periodontal disease, others
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Pivotal Trial (Near Approval)This treatment is in the last trial phase before FDA approval
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

Triple Blinded Randomized Clinical trial study to assess the efficacy of two brushing regimens: 1) a toothpaste containing stannous fluoride and a standard manual toothbrush as compared to 2) a regular fluoride toothpaste and standard manual toothbrush in the reduction of established dental plaque and gingivitis.

Are You a Good Fit for This Trial?

This trial is for adults aged 18-70 who are generally healthy, have at least 20 natural teeth (not counting wisdom teeth), and already show some gum inflammation and plaque buildup. Participants must be available for a 6-month study.

Inclusion Criteria

* Signed Informed Consent Form.
* Availability for the twenty four-week(6 month) duration of the clinical research study.
I am in good health and have at least 20 natural teeth, not counting wisdom teeth.
See 3 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants use either a toothpaste containing stannous fluoride or a regular fluoride toothpaste with a standard manual toothbrush

24 weeks
Baseline, 12 weeks, 24 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Colgate Great Regular Flavor Toothpaste
  • Colgate SNaP Total 10/10, 1.5 Taurate

Trial Overview

The study compares two tooth brushing routines: one uses a toothpaste with stannous fluoride and the other uses regular fluoride toothpaste. Both groups use standard manual toothbrushes to see which routine better reduces dental plaque and gum disease.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Test 1 toothpasteExperimental Treatment2 Interventions
Group II: Control toothpasteActive Control2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Colgate Palmolive

Lead Sponsor

Trials
106
Recruited
19,100+

Noel Wallace

Colgate Palmolive

Chief Executive Officer since 2019

MBA from Harvard Business School

Diana Haussling

Colgate Palmolive

Chief Marketing Officer since 2022

Bachelor's degree in Marketing

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