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Atezolizumab + Varlilumab (+/- Cobimetinib) for Biliary Tract Cancer
Study Summary
This trial is investigating whether combining atezolizumab with varlilumab, with or without cobimetinib, is effective in treating biliary tract cancer that cannot be removed by surgery.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Frequently Asked Questions
In what treatments is Cobimetinib typically utilized?
"In addition to small cell lung cancer (SCLC), Cobimetinib can also be deployed for more advanced stages of melanoma, as well as other types of malignant neoplasms."
Has a study of this kind ever been conducted before?
"Since 2008, Cobimetinib has been the subject of ongoing research. Hoffmann-La Roche sponsored the initial trial in 2008 and following successful results, it was approved at Phase 2. Currently there are 379 active trials taking place across 1651 cities and 74 countries worldwide."
What is the upper limit of participants undertaking this clinical study?
"This study necessitates 64 appropriate participants to fulfil its requirements. Patients have the ability to join from Wake Forest University Health Sciences in Winston-Salem, North carolina or Laura and Isaac Perlmutter Cancer Center at NYU Langone in New york, Illinois."
What safety protocols have been established for Cobimetinib use?
"Cobimetinib's safety score was rated as a 2, due to Phase 2 data indicating some level of security but no efficacy evidence."
Are there any other research studies that are using Cobimetinib as a therapeutic intervention?
"Cobimetinib was initially studied in 2008 by the SCRI Tennessee Oncology Chattanooga. After 230 completed trials, there are now 379 clinical studies actively recruiting patients across numerous locations with a primary center being Winston-Salem, North carolina."
Is there still room for participants in this experiment?
"Indeed, the information about this trial hosted on clinicaltrials.gov is accurate. This study was first posted in September 2021 and its most recent update occurred in November 2022. Currently, 64 individuals are required to participate from 30 different medical facilities."
Are there several sites hosting this research project in the United States?
"This trial is being conducted across 30 medical centres, including those in Winston-Salem, New york City and Chicago. If you're participating in the study it's wise to select a clinic close to your home location so as to minimize transportation needs."
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