HIPEC during Surgery for Ovarian Cancer
(HIPEC Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial protocol does not specify if you need to stop taking your current medications. However, it does require that you have completed a specific course of platinum-based chemotherapy before participating.
What data supports the effectiveness of the treatment HIPEC during surgery for ovarian cancer?
Research shows that combining surgery with heated chemotherapy (HIPEC) can be effective for treating cancers in the abdomen, including ovarian cancer, especially in patients who have not responded well to other treatments. This approach has been used successfully in other types of abdominal cancers, suggesting it may help improve outcomes for ovarian cancer patients as well.12345
Is HIPEC during surgery for ovarian cancer generally safe for humans?
How is the HIPEC treatment with carboplatin during surgery for ovarian cancer different from other treatments?
What is the purpose of this trial?
The purpose of this research study is to see if it is feasible to receive heated chemotherapy or heated intraperitoneal chemotherapy (HIPEC) inserted directly into the abdomen at the time of a Second Look Reassessment Surgery and to monitor any effects good or bad that this has on participants' health.
Research Team
Laurel Berry, MD
Principal Investigator
Wake Forest University Health Sciences
Eligibility Criteria
This trial is for adults over 18 with specific types of ovarian, fallopian tube, or peritoneal cancer. Participants must have completed certain surgeries and chemotherapy within a set timeframe, have no current evidence of disease, and meet specific health criteria like organ function. Pregnant individuals or those with recent infections, severe allergies to carboplatin, or unstable health conditions are excluded.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo second look laparoscopy and may receive hyperthermic intraperitoneal chemotherapy (HIPEC) with carboplatin if visible signs of cancer are present.
Follow-up
Participants are monitored for quality of life and toxicities using the FACT-O questionnaire and CTCAE criteria.
Treatment Details
Interventions
- Carboplatin
- Second look laparoscopy reassessment surgery (SLLRS)
Carboplatin is already approved in United States, European Union, Canada for the following indications:
- Ovarian cancer
- Testicular cancer
- Lung cancer
- Head and neck cancer
- Brain cancer
- Ovarian cancer
- Small cell lung cancer
- Ovarian cancer
- Small cell lung cancer
- Testicular cancer
Find a Clinic Near You
Who Is Running the Clinical Trial?
Wake Forest University Health Sciences
Lead Sponsor
National Cancer Institute (NCI)
Collaborator