Topical Creams for TMJ Pain
Trial Summary
Will I have to stop taking my current medications?
The trial requires that you stop taking any steroids and muscle relaxants before participating. You can start muscle relaxants again after the study is complete.
What evidence supports the effectiveness of the drug for TMJ pain?
Is topical diclofenac safe for treating TMJ pain?
How is the topical cream treatment for TMJ pain different from other treatments?
The topical cream treatment for TMJ pain is unique because it combines diclofenac, a non-steroidal anti-inflammatory drug (NSAID), and hydrocortisone, a corticosteroid, to reduce pain and inflammation directly at the site of application, potentially minimizing systemic side effects compared to oral medications.12358
What is the purpose of this trial?
The goal of this clinical trial is to evaluate the efficacy of topical 2.5% hydrocortisone in TMJ arthralgia. The main questions it aims to answer are:* How does pain reduction compare?* How does improvement in jaw function limitation compare?* How do side effects compare? Participants will* On day 1 be examined and report their pain level and jaw function limitation* On days 1-21, apply their cream four times a day* On day 21, report their pain level, jaw function limitation, compliance with instructions, and side effects.Researchers will compare topical 2.5% hydrocortisone and topical 1% diclofenac to see if efficacy and side effects differ.
Eligibility Criteria
This trial is for individuals experiencing pain in at least one temporomandibular joint (TMJ) for a minimum of three days. It's not suitable for those with systemic pain conditions, past steroid reactions, current or recent steroid use, or those who've started using muscle relaxants or a new night guard around the study period.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants apply topical cream four times a day for 21 days
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Diclofenac 1% topical
- Hydrocortisone 2.5%
Diclofenac 1% topical is already approved in European Union, United States, Canada, Japan for the following indications:
- Pain relief
- Inflammation
- Arthritis
- Musculoskeletal disorders
- Pain relief
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Pain relief
- Inflammation
- Arthritis
- Musculoskeletal disorders
- Pain relief
- Inflammation
- Arthritis
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of the Pacific
Lead Sponsor