Ketamine for Sickle Cell Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical trial is to learn if the use of early ketamine decreases the chance of admission to the hospital in patients with sickle cell disease presenting with pain.
The main questions this study aims to answer are:
* Does ketamine given within 1 hour of acute care presentation decrease the chance of hospital admission?
* If admitted, does continuing ketamine in the first few hours of admission decrease opioid use or length of stay compared to those who start it later in the admission?
Researchers will compare the study arm to patients with sickle cell disease who receive placebo within 1 hour of presentation for the first aim.
Participants will be given ketamine/placebo by mouth without 1 hour of presentation.
If admitted, all participants will be able to start open label IV ketamine upon admission to the floor based on their clinical needs. Participants who end up starting ketamine will be reviewed to determine if early start to ketamine is helpful in reducing opioid use and length of stay.
Who Is on the Research Team?
Natasha Archer
Principal Investigator
Boston Children's Hospital
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a single dose of oral ketamine or placebo within 1 hour of acute care presentation
Hospital Admission and Open-label Treatment
If admitted, participants may start open-label IV ketamine upon admission to the floor based on clinical needs
Follow-up
Participants are monitored for safety and effectiveness after treatment, including readmission rates and satisfaction surveys
What Are the Treatments Tested in This Trial?
Interventions
- Ketamine
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Single dose of oral ketamine 0.5mg/kg (max dose of 35mg)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Boston Children's Hospital
Lead Sponsor
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