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Ixazomib + Chemotherapy for Kidney Cancer
Study Summary
This trial is studying a combination of drugs to treat kidney cancer. Ixazomib may stop the growth of tumor cells by blocking some enzymes needed for cell growth. Gemcitabine and doxorubicin work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2021 Phase 4 trial • 45 Patients • NCT03416374Trial Design
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- Your heart pumps blood at a healthy rate, at least 45%.It doesn't matter if my kidney tumor has been removed or is still there.I am not pregnant, breastfeeding, and if capable of having children, I am using effective birth control.I am 12 or older and have both my agreement and my parents' consent.My white blood cell count is healthy without needing medication.My liver enzymes are within normal limits, except I have liver metastasis.I have not been diagnosed or treated for another cancer within the last 2 years.I have not had cancer treatment within the restricted time.My cancer has spread to my brain or its coverings and is not under control.You have a positive test for hepatitis B virus (HBV) or hepatitis C virus (HCV).Your total bilirubin level must be less than or equal to 1.5 mg/dl.My kidney tumor is rare, advanced, or has spread, and lacks SMARCB1.I have at least one tumor that can be measured.I have had immunotherapies or targeted therapies before.I am able to get out of my bed or chair and move around.Your blood clotting tests should be within a certain range before joining the study.I am following the required pregnancy prevention measures.I am a male and follow the required birth control guidelines.I have not had major surgery or significant injury recently.My nerve damage does not severely affect my daily activities.I still have side effects from my last chemotherapy.My cancer is advanced or has spread, and tests show a specific protein is missing.I have a stomach or intestine condition that affects how I absorb pills.Your hemoglobin level is 9 grams per deciliter or higher.Your kidneys work well enough to filter out waste from your blood.I haven't taken certain medications in the last 14 days.My brain metastases are under control and meet specific criteria.Your platelet count is at least 75,000 per microliter.Your condition has worsened despite the last treatment you received.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Does this research endeavor employ any untested methods?
"Currently, there are 910 ongoing clinical trials involving Ixazomib across 88 countries and 2947 cities. This drug's research history began in 1997 with a Phase 3 study sponsored by Alfacell that recruited 300 patients; since then, 1665 experiments have been conducted."
How many participants are involved in this clinical exploration?
"Affirmative. Clinicaltrials.gov indicates that this clinical trial, which was initially established on August 17th 2018, is now inviting patients to join the study. 30 individuals need to be admitted from one medical site."
Are individuals still able to volunteer for this experiment?
"Affirmative. Clinicaltrials.gov attests that this therapeutic trial, which was initially posted on August 17th 2018, is currently recruiting subjects. Around 30 participants must be enrolled from 1 site."
What prior experiments have been conducted with Ixazomib?
"At the moment, 910 trials are running to study Ixazomib and 270 of those have reached Phase 3. As most studies focus on Shanghai, there is an impressive 52285 locations offering these medical experiments."
What ailments are commonly remedied through Ixazomib administration?
"Ixazomib is a viable solution for treating Sezary Syndrome, Mesotheliomas and advanced Non small cell lung cancer (NSCLC)."
Has Ixazomib been granted regulatory clearance yet?
"Our internal assessment of Ixazomib's safety at Power is a 2. This rating was given due to the fact that this particular trial is in Phase 2, which indicates there has been some prior testing on its security but none regarding efficacy."
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