Study Summary
This trial will compare treatments for Severe Aplastic Anemia, a rare condition where the body stops producing blood cells. Treatment includes immune suppressive therapy or a bone marrow transplant.
- Severe Aplastic Anemia
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 27 Secondary · Reporting Duration: Randomization to one year, randomization to two years
Trial Safety
Safety Progress
Trial Design
2 Treatment Groups
Matched Unrelated Stem Cell Transplant
1 of 2
Immunosuppressive Therapy
1 of 2
Active Control
234 Total Participants · 2 Treatment Groups
Primary Treatment: Matched Unrelated Stem Cell Transplant · No Placebo Group · Phase 3
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age No minimum age - 25 · All Participants · 6 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
What risks may be associated with Immunosuppressive Therapy?
"Immunosuppressive Therapy is assessed as safe, garnering a score of 3. This can be attributed to evidence from both Phase 3 trials and further clinical research that shows efficacy for this treatment option." - Anonymous Online Contributor
Could you provide the upper limit of participants involved in this experiment?
"Affirmative. Clinicaltrials.gov confirms that this investigation, which was first published on January 1st 2023, is actively recruiting participants. A total of 234 individuals need to be enrolled from one medical center." - Anonymous Online Contributor
Does this study have an age restriction, and if so, what is the cutoff for participation?
"By examining the inclusion criteria, it becomes apparent that this trial is available to those between 0 and 25 years of age. For younger patients (under 18) there are 100 clinical studies while for elderly individuals (over 65), 169 trials exist." - Anonymous Online Contributor
Is this experiment currently accepting participants?
"Affirmative. Based on the information located on clinicaltrials.gov, this research is actively enrolling patients. The trial was first posted on January 1st 2023 and its data points have been updated as recently as September 1st of the same year. A total of 234 people will be admitted at one site for participation in this study." - Anonymous Online Contributor
Do I fulfill the requirements to partake in this medical experiment?
"This trial seeks 234 individuals aged 0 to 25 with severe aplastic anemia. Furthermore, they must provide signed consent, possess no fully matched related donor, have at least two unrelated donors noted on their National Marrow Donor Program search that are well-matched (9/10 or 10/10 for HLA-A, B, C., DRB1 and DQB1 using high resolution), demonstrate bone marrow cellularity below 25% or hematopoietic cells <30%, display two of the following three in peripheral blood: neutrophils lower than 0.5 x 10^9/L; platelets" - Anonymous Online Contributor