Flax Muffins for High Cholesterol
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how well flax muffins can lower LDL cholesterol, often called "bad" cholesterol. The researchers aim to determine the smallest effective amount of flax. Participants will be divided into groups, with some eating muffins containing varying amounts of flax each day for four weeks. The trial seeks individuals with stable eating habits and moderately high LDL cholesterol who are not on cholesterol or blood pressure medications. As an unphased trial, participation offers a chance to contribute to understanding dietary impacts on cholesterol.
Will I have to stop taking my current medications?
If you are taking cholesterol-lowering or blood pressure-lowering medications, or any medication known to affect blood lipids, you would not be eligible for this trial. The protocol does not specify about other medications, but you should discuss your current medications with the trial team.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that flaxseed often helps with health issues like high cholesterol, diabetes, and weight problems. Studies have found that flaxseed can improve health indicators such as blood pressure and cholesterol, suggesting it is likely safe for many people.
Flaxseed contains omega-3 fatty acids, which benefit heart health. Some people might experience mild side effects, such as bloating or gas, but these are usually not serious. Since this trial tests different amounts of flaxseed in muffins, it appears safe based on existing knowledge about flaxseed.
In summary, flaxseed is generally well-tolerated, but it's always important to monitor how the body reacts.12345Why are researchers excited about this trial's treatments?
Unlike the standard treatments for high cholesterol, which often include statins and lifestyle changes, flax muffins offer a unique approach by using ground flaxseed as the active ingredient. Flaxseed is rich in omega-3 fatty acids and fiber, both of which are believed to help reduce cholesterol levels naturally. Researchers are excited about this treatment because it provides a simple, dietary alternative that could appeal to those seeking natural or non-pharmaceutical options. Plus, incorporating flaxseed into a daily diet through something as accessible as a muffin could make it easier for people to stick with their treatment plan.
What evidence suggests that flax muffins could be effective for lowering high cholesterol?
Research has shown that flaxseed can help lower LDL cholesterol, often referred to as "bad" cholesterol. Studies have found that consuming flaxseed significantly reduces LDL levels. In one study, participants who ate flaxseed had lower cholesterol than those who did not. Another study found that flaxseed not only lowered LDL cholesterol but also reduced total cholesterol and triglycerides, which are fats in the blood. These findings suggest that flaxseed may effectively lower cholesterol levels. This trial will compare the effects of consuming muffins with different amounts of ground flaxseed—0g, 20g, and 30g per day—on cholesterol levels.16789
Who Is on the Research Team?
Heather J Blewett, PhD
Principal Investigator
Agriculture and Agri-Food Canada
Thomas Wolever, PhD, MD
Principal Investigator
University of Toronto
Are You a Good Fit for This Trial?
This trial is for adults with a BMI of 18.5-40 who have high LDL cholesterol levels (2.6-5.0 mmol/L) but no history of cardiovascular disease, diabetes, liver or kidney issues, and aren't on medications affecting blood lipids. They should eat regular meals and not be on weight loss programs or consume excessive alcohol.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants consume muffins containing varying doses of ground flaxseed daily to study LDL cholesterol lowering effects
Follow-up
Participants are monitored for safety and effectiveness after treatment, including gastrointestinal side effects, liver and kidney function, and lipid profile
What Are the Treatments Tested in This Trial?
Interventions
- Flax Muffin
Find a Clinic Near You
Who Is Running the Clinical Trial?
St. Boniface Hospital
Lead Sponsor
Agriculture and Agri-Food Canada
Collaborator