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Virus Therapy

Yellow Fever Vaccine for Yellow Fever

Phase 1 & 2
Waitlist Available
Led By Timothy Schacker, MD
Research Sponsored by University of Minnesota
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
No contraindication to Yellow Fever vaccine (immunosuppressed for any reason or on an immunosuppressive drug where a live virus vaccine is contraindicated).
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 18 months
Awards & highlights

Study Summary

This trial will study the effect of yellow fever vaccination on two cohorts, one from Uganda and one from Minnesota. Lymphoid tissues and peripheral blood monocytes will be collected before and after vaccination to catalog the individual's infectious burden and determine the relationship between infections and immunity.

Who is the study for?
This trial is for healthy adults without immune system issues who haven't had the yellow fever vaccine before. Women of childbearing age must avoid pregnancy for a month after vaccination. People with bleeding disorders, severe allergies to vaccine components, or those on immunosuppressive therapy cannot join.Check my eligibility
What is being tested?
The study tests how the yellow fever vaccine affects lymph node structures and immunity in two groups: one from Uganda and another from Minnesota. It involves blood samples and tissue collection before and after vaccination to assess inflammation and immune response.See study design
What are the potential side effects?
While not specified here, common side effects of the yellow fever vaccine may include mild headache, muscle pain, low-grade fever, soreness at injection site, or fatigue.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am not on any medication that weakens my immune system.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~18 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 18 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Peak Neutralizing Antibody Titer

Side effects data

From 2012 Phase 3 trial • 552 Patients • NCT01466387
4%
Headache
2%
Injection site pain
2%
Influenza like illness
1%
Nasopharyngitis
100%
80%
60%
40%
20%
0%
Study treatment Arm
MenACWY-CRM197 (Combined)
JE+Rabies+MenACWY-CRM197
TF+YF+MenACWY-CRM197
JE+Rabies
Rabies
TF+YF

Trial Design

1Treatment groups
Experimental Treatment
Group I: All ParticipantsExperimental Treatment1 Intervention
In this single-arm study, all participants will receive the intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Yellow Fever Vaccine
2016
Completed Phase 4
~1490

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

University of MinnesotaLead Sponsor
1,378 Previous Clinical Trials
1,588,466 Total Patients Enrolled
National Institute of Allergy and Infectious Diseases (NIAID)NIH
3,268 Previous Clinical Trials
5,481,089 Total Patients Enrolled
8 Trials studying Yellow Fever
1,082 Patients Enrolled for Yellow Fever
Timothy Schacker, MDPrincipal InvestigatorUniversity of Minnesota
7 Previous Clinical Trials
66 Total Patients Enrolled

Media Library

Yellow Fever Vaccine (Virus Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT04269265 — Phase 1 & 2
Yellow Fever Research Study Groups: All Participants
Yellow Fever Clinical Trial 2023: Yellow Fever Vaccine Highlights & Side Effects. Trial Name: NCT04269265 — Phase 1 & 2
Yellow Fever Vaccine (Virus Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04269265 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any available slots for participants in this research study?

"As evidenced on clinicaltrials.gov, this experiment is open for participation; it was first posted on the 1st of July 2020 and revised most recently on October 19th 2022."

Answered by AI

How many participants are included in this clinical experiment?

"Affirmative. Clinicaltrials.gov's information shows that the trial is currently searching for participants, with a posting date of July 1st 2020 and an update on October 19th 2022. 46 people are needed from one medical facility to join this research initiative."

Answered by AI

Do the criteria for this study include individuals below 25 years of age?

"Participants aged 18 to 60 are eligible for this trial. However, there currently exists 53 studies aimed at minors and 337 trials that focus on those 65 or older."

Answered by AI

Could you please outline the precedent of Yellow Fever Vaccine research?

"Currently, there is an active cohort of seven clinical trials exploring the efficacy of Yellow Fever Vaccine. None are in Phase 3 and most are based around Madrid, Comunidad De; however, 59 other sites across the globe are engaged in similar research."

Answered by AI

What requirements must be met to qualify for participation in this research project?

"This clinical trial is seeking 46 individuals suffering from yellow fever, who are between 18 and 60 years of age. Eligibility necessitates that the patient should not be immunocompromised or taking medications which might interfere with a live virus vaccine."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
The Effect of Inflammation and Damage to Lymph Node Structures on Durable Protective Immunity Following Yellow Fever Vaccination
2020. "The Effect of Inflammation and Damage to Lymph Node Structures on Durable Protective Immunity Following Yellow Fever Vaccination". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04269265.
~10 spots leftby Jun 2025
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