Trimethoprim for Prostate Cancer
Trial Summary
Will I have to stop taking my current medications?
You may need to stop taking certain medications, especially those containing folic acid or potassium, and any that might interact with trimethoprim. It's important to discuss your current medications with the trial team to see if any changes are needed.
How does the drug Trimethoprim differ from other treatments for prostate cancer?
Trimethoprim is unique in the context of prostate cancer treatment as it is primarily an antibiotic used to treat bacterial infections, unlike other drugs like cyclophosphamide or methotrexate, which are traditional chemotherapy agents. Its use in prostate cancer is novel and not part of the standard treatment options, which typically involve hormone therapy or chemotherapy with drugs specifically tested for cancer.12345
What is the purpose of this trial?
The researchers hope to learn if Trimethoprim, 150mg taken daily for 3 months, is a safe and effective way to reduce folate levels at time of Androgen Deprivation Therapy (ADT) in men with advanced prostate cancer.This study will help find out what effects, good and/or bad, this drug has on people who take it and on its effect on the disease. The safety of this drug in humans has been tested in prior research studies; however, some side effects may not yet be known.
Research Team
Michael A. Liss
Principal Investigator
The University of Texas Health Science Center at San Antonio
Eligibility Criteria
This trial is for men with advanced prostate cancer who are about to start Androgen Deprivation Therapy (ADT). Participants should be willing to take Trimethoprim daily for 3 months. Specific eligibility criteria were not provided, so interested individuals should contact the study organizers for more details.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive Trimethoprim, 150mg daily for 3 months, alongside standard of care androgen deprivation therapy
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessments of serum folate levels, RBC folate, PSA levels, and microbiome analysis
Long-term Follow-up
Participants' testosterone levels are monitored to determine progression-free survival
Treatment Details
Interventions
- Trimethoprim
Find a Clinic Near You
Who Is Running the Clinical Trial?
The University of Texas Health Science Center at San Antonio
Lead Sponsor