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Combination Immunotherapy + Radiation for Cancer
Study Summary
This trial is testing a combination of 4 therapies to see if they are more effective than each therapy alone. 3 of the therapies are used to treat a single "target site" of your cancer, and the 4th is given directly into the blood stream.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2024 Phase 2 trial • 57 Patients • NCT03004183Trial Design
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Who is running the clinical trial?
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- I am not allergic to pembrolizumab, poly-ICLC, Flt3L, or their ingredients.You have a current, active infection of Hepatitis B or Hepatitis C.I haven't had cancer treatment with monoclonal antibodies in the last 28 days or have recovered from their side effects.I have another cancer, but it's either being treated or not getting worse, except for certain skin, cervical, anal, or stable prostate cancers.I do not have transformed lymphoma or grade 3A follicular lymphoma.I have stable brain metastases, not on steroids for 7 days, and no leptomeningeal disease.I have fully recovered from any major surgery before starting treatment.I haven't had cancer treatment in the last 14 days or have recovered from side effects.I have had or currently have lung inflammation treated with steroids.My cancer is either iNHL, MBC, or HNSCC.My lymphoma type is small lymphocytic.I haven't needed strong medication for an autoimmune disease in the last year.I do not need immediate cancer treatment.I have been diagnosed with grade 3B follicular lymphoma.My cancer is not just in my stomach and is safe for injections.I am currently being treated for an infection.I am HIV positive with a detectable viral load and not on a stable HAART regimen.I had radiotherapy over 2 weeks ago, recovered from side effects, and didn't have lung inflammation from it.I have not used any experimental drugs or devices in the last 28 days.You have had a transplant using cells or organs from another person.I am not on high-dose steroids or other drugs that weaken my immune system.I have not received a live vaccine in the last 30 days.
- Group 1: Combination therapy
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many participants are being admitted to this clinical trial?
"Indeed, the clinicaltrials.gov website verifies that recruitment for this medical research is ongoing; its listing was first created on April 5th 2019 and most recently updated on October 18 2021. This investigation necessitates 56 participants from a single site."
What therapeutic applications is Pembrolizumab most widely administered for?
"Pembrolizumab is primarily used to treat cancerous neoplasms, though it has been known to help those with melanoma that cannot be surgically resected, microsatellite instability high cases, and individuals whose disease progressed past chemotherapy."
Are there any enrollment opportunities available for this experiment?
"Data on clinicaltrials.gov asserts that this medical trial is actively enlisting participants, with the initial post being dated April 5th 2019 and most recently modified October 18th 2021."
What previous experiments have been done to assess the effectiveness of Pembrolizumab?
"Presently, there are 961 clinical trials for Pembrolizumab; of which 122 have entered Phase 3. Most studies related to this drug occur in Houston, Texas though it is being tested at 35731 trial locations worldwide."
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