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Mosunetuzumab +/- Polatuzumab Vedotin for Diffuse Large B-Cell Lymphoma
Study Summary
This trial will test a new drug, mosunetuzumab, for safety and effectiveness in treating DLBCL, a type of lymphoma.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2019 Phase 1 & 2 trial • 231 Patients • NCT01691898Trial Design
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Who is running the clinical trial?
Media Library
- I have a significant history of liver problems.I have a tumor that can be measured and is larger than 1.5 cm if it's in a lymph node or larger than 1.0 cm if it's not in a lymph node.My blood counts are within a healthy range.I can care for myself and am under 80 if living in South Korea.My lymphoma has changed into a more aggressive form.I have been treated with mosunetuzumab before.I have been diagnosed with progressive multifocal leukoencephalopathy.I have or might have chronic Epstein Barr, hepatitis B, hepatitis C, or HIV.I have had a solid organ transplant.I have not had radiotherapy in the last 2 weeks.I have a serious heart condition.I had treatment for lymphoma more than 4 weeks ago.I have received chemotherapy, immunotherapy, and biologic therapy for DLBCL.I do not have severe nerve damage or a specific nerve disease.I am over 65 and have a specific type of lymphoma (DLBCL) that has not been treated.I have DLBCL, treated once with a specific chemo mix, and didn't fully recover.I have or had a brain-related condition like stroke or epilepsy.I have had a stem cell transplant before.My condition is CNS lymphoma.I have or might have had HLH in the past.
- Group 1: Consolidation Therapy (Cohort A)
- Group 2: Elderly/Unfit Previously Untreated Monotherapy (Cohort B)
- Group 3: Elderly/Unfit Previously Untreated Combination Therapy (Cohort C)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Where are the sites of this clinical trial?
"Presently, this clinical trial is enrolling patients from 11 sites which are situated in Philadelphia, New york, Miami and 8 other locations. If you wish to take part in the study, it would be advantageous to select a site near your residence to limit travel."
What are the main indications for Polatuzumab Vedotin?
"Polatuzumab vedotin is often used in therapeutic procedures. Additionally, it has shown to be effective the treatment of dlbcl, sjia, and cytokine release syndrome car-t cell therapy."
Are there any similar studies to Polatuzumab Vedotin that have already been completed?
"Currently, there are a total of 92 clinical trials studying Polatuzumab Vedotin. Out of those, 12 have progressed to Phase 3 testing. Although the majority of these studies originated in Tbilisi and New york, 2206 medical centres worldwide are trialling this medication."
Are investigators still looking for participants for this research project?
"That is correct, the public information available on clinicaltrials.gov does show that this research project is still enrolling patients. The 188 participants will be recruited from 11 hospitals or clinics across the country. This particular trial was first posted on May 23rd, 2019 and was most recently updated on November 8th, 2020."
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