ARBs + Statins for Dementia

(VISTA Trial)

HY
Overseen ByHussein Yassine, MD
Age: 18+
Sex: Any
Trial Phase: Phase 2
Sponsor: University of Southern California
Must be taking: ARBs, Statins
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

The proposed pharmacist-led study is a feasibility pilot trial for the management of vascular risk factors of hypertension and hypercholesterolemia in 10 APOE ε4 carriers, 50-75, at-risk for dementia. All participants will receive angiotensin receptor blockers (ARBs) for high blood pressure, and hydrophilic statins (or a non-statin alternative) for high cholesterol over a six-month period.

Are You a Good Fit for This Trial?

Inclusion Criteria

I have tested positive for the APOE ε4 gene.
* LDL-C of 100-250 mg/dL
* Systolic blood Pressure (SBP) 130-180 mm Hg
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive pharmacist-led management of hypertension and hypercholesterolemia using angiotensin receptor blockers and hydrophilic statins (or non-statin alternatives) over six months

6 months

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Angiotensin Receptor Blockers (ARBs)
  • Hydrophilic Statins or Non-Statin Alternative

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Pharmacist-Led Vascular Risk Factor ManagementExperimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Southern California

Lead Sponsor

Trials
956
Recruited
1,609,000+