40 Participants NeededMy employer runs this trial

ALN-4324 for Type 2 Diabetes

AC
Overseen ByAlnylam Clinical Trial Information Line
Age: 18+
Sex: Any
Trial Phase: Phase 2
Sponsor: Alnylam Pharmaceuticals
Must be taking: Metformin
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to evaluate the effect of a single dose of ALN-4324 on whole-body insulin sensitivity in participants with T2DM

Who Is on the Research Team?

MD

Medical Director

Principal Investigator

Alnylam Pharmaceuticals

Are You a Good Fit for This Trial?

Inclusion Criteria

I am an adult diagnosed with type 2 diabetes.
* Has a body mass index (BMI) of ≥25 kg/m\^2 and \<39.9 kg/m\^2
I am taking a stable dose of metformin.
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive a single dose of ALN-4324 or placebo

Single dose

Follow-up

Participants are monitored for changes in insulin sensitivity and other measures

6 months

What Are the Treatments Tested in This Trial?

Interventions

  • ALN-4324

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Placebo Group

Group I: ALN-4324Experimental Treatment1 Intervention
Group II: PlaceboPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Alnylam Pharmaceuticals

Lead Sponsor

Trials
81
Recruited
16,100+

Dr. Yvonne Greenstreet

Alnylam Pharmaceuticals

Chief Executive Officer since 2021

MD from the University of Leeds, MBA from INSEAD

Dr. Pushkal Garg

Alnylam Pharmaceuticals

Chief Medical Officer since 2016

MD from Columbia University