Gamma Frequency Sensory Stimulation for Alzheimer's Disease
(GENUS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Despite the huge healthcare and economic impact of AD, there is still no disease modifying therapeutics available. In fact, the available therapeutics show low efficacy at best in the treatment of cognitive impairment in dementia. Development of a non-invasive medical device that is effective in slowing cognitive impairment is not only revolutionary but also possibly cost- effective. In this study, participants will come to MIT for a 1-day visit and the investigators will evaluate the effects of GENUS in cognitively normal, healthy adults. Investigators will use Electroencephalogram (EEG), Magnetoencephalography (MEG), magnetic resonance imaging (MRI), neuropsychological testing, and blood sampling in subsets of participants to evaluate for biological effects and safety of GENUS stimulation.
Who Is on the Research Team?
Ana Trisini Lipsanopoulos, BS
Principal Investigator
Massachusetts Institute of Technology
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a single session of 40Hz sensory stimulation to evaluate effects on brain activity, connectivity, neuropsychological measures, blood biomarkers, and the microbiome.
Follow-up
Participants are monitored for safety and effectiveness after treatment, with evaluations of brain oscillations, microbiome, blood biomarkers, and neuropsychiatric measures over a 1-year period.
What Are the Treatments Tested in This Trial?
Interventions
- GENUS
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Cognitively normal, healthy adults aged 18 - 100
Find a Clinic Near You
Who Is Running the Clinical Trial?
Massachusetts Institute of Technology
Lead Sponsor
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