Accelerated Radiation Therapy for Breast Cancer
(ASHBY Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to compare any good and bad effects of giving radiation treatment for breast cancer in 3 treatments over about 2 days.
Do I need to stop my current medications for this trial?
The trial protocol does not specify whether you need to stop taking your current medications. However, if your tumor is HER2-positive, you must continue with HER2-directed therapy.
Is accelerated radiation therapy for breast cancer safe?
Research shows that accelerated radiation therapy, including various hypofractionated schedules, is generally safe for breast cancer patients. Studies have reported no significant increase in adverse effects compared to traditional schedules, and trials like UK-FAST and FAST-Forward have demonstrated safe toxicity profiles with long-term follow-up.12345
How is the Accelerated Super-Hypofractionated Breast Brachytherapy treatment different from other breast cancer treatments?
What data supports the effectiveness of the treatment Accelerated Super-Hypofractionated Breast Brachytherapy (ASHBY) for breast cancer?
Research shows that accelerated hypofractionated radiotherapy, which is similar to ASHBY, is effective for early breast cancer, offering a shorter treatment time with good tolerance and efficacy. This approach involves delivering higher doses of radiation in fewer sessions, which has been shown to be effective in treating breast cancer after surgery.267810
Who Is on the Research Team?
Bridget Quinn, MD, Ph.D
Principal Investigator
Virginia Commonwealth University
Are You a Good Fit for This Trial?
This trial is for individuals with breast cancer who are eligible for radiation therapy. Specific eligibility criteria are not provided, but typically participants would need to have a certain stage of cancer and be in good enough health to undergo the treatment.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Radiation
Participants receive accelerated partial breast irradiation (APBI) with a multicatheter interstitial implant over 1.5 days
Follow-up
Participants are monitored for safety, effectiveness, and cosmetic outcomes after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Accelerated Super-Hypofractionated Breast Brachytherapy
Accelerated Super-Hypofractionated Breast Brachytherapy is already approved in United States, European Union, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
Virginia Commonwealth University
Lead Sponsor